Evidence map›Paper›PMID 41374921›Full record

ArticlePolymers2025

Preparation of Alginate/AgNP Nanocomposite Hydrogels Incorporating Olive Leaf Extracts in Natural Deep Eutectic Solvents.

Ioanna Pitterou, Athina Tzavara Roussi, Aikaterini Malliaraki, Elli Martina Kousouli, Andromachi Tzani, Konstantinos Tsiantas, Anthimia Batrinou, Christina Fountzoula, Anastasios Kriebardis, Panagiotis Zoumpoulakis and 1 more

Abstract read
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In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ioanna PitterouLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.ORCID 0009-0005-1937-287X
Athina Tzavara RoussiLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.
Aikaterini MalliarakiLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.
Elli Martina KousouliLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.ORCID 0000-0003-0552-1502
Andromachi TzaniLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.ORCID 0009-0009-1348-7114
Konstantinos TsiantasLaboratory of Chemistry, Analysis and Design of Food Processes, Department of Food Science and Technology, University of West Attica, 12243 Athens, Greece.ORCID 0000-0003-2576-9142
Anthimia BatrinouLaboratory of Chemistry, Analysis and Design of Food Processes, Department of Food Science and Technology, University of West Attica, 12243 Athens, Greece.ORCID 0000-0001-8219-7537
Christina FountzoulaLaboratory of Chemistry, Biochemistry and Cosmetic Science, Department of Biomedical Sciences, School of Health and Caring Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0000-0002-3765-2112
Anastasios KriebardisLaboratory of Reliability and Quality Control in Laboratory Hematology, Department of Biomedical Sciences, School of Health and Caring Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0000-0003-3915-1829
Panagiotis ZoumpoulakisLaboratory of Chemistry, Analysis and Design of Food Processes, Department of Food Science and Technology, University of West Attica, 12243 Athens, Greece.
Anastasia DetsiLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.ORCID 0000-0001-8325-2980

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, alginate-silver nanoparticle (Alg-AgNP) nanocomposite hydrogels possessing antibacterial activity were synthesized via an innovative route. A task-specific designed Natural Deep Eutectic Solvent (NADES), composed of glucose, lactic acid, and water, was utilized as a green extraction solvent of bioactive compounds from olive leaves (OLs). The NADES-olive leaf extract (NADES-OLE) was used as obtained for the preparation of the Alg-AgNP nanocomposite hydrogel as a multiple-role component. The NADES-OLE acts (a) as a crosslinking agent for the preparation of the alginate hydrogels, (b) as a reducing agent for the in situ synthesis of AgNPs during hydrogel formation, and (c) as a bioactivity enhancement agent due to the presence of compounds obtained from the olive leaves. The Alg-AgNP hydrogel preparation process was optimized through a Box-Behnken experimental design. The resulting nanocomposite hydrogels were characterized for their swelling capacity and water retention in phosphate buffer (pH 5.5), achieving 538% swelling capacity within 180 min and 90% water retention after 250 min. The AgNPs formed within the hydrogels were found to have an average size of 103.2 ± 5.6 nm, with a concentration of 1.2 10

Indexed as

antibacterial activitygreen nanotechnologyNADESnanocomposite hydrogelssilver nanoparticles

Identifiers

PMID41374921
PMCPMC12694050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.