Evidence map›Paper›PMID 41374803›Full record

ArticlePolymers2025

3D Nanofibrous Scaffolds for Encapsulation-Controlled Vancomycin Delivery: Antibacterial Performance and Cytocompatibility.

Tatiana Rita de Lima Nascimento, Aline Lima Guérin, Mariana Souza Rodrigues, Camila Félix da Silva, Bruno Martins Maciel, Abdulaziz Alhotan, Saleh Alhijji, Marilia Mattar Amoêdo Campos Velo, Lúcio Roberto Cançado Castellano

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatiana Rita de Lima NascimentoInstitute for Emerging Electronic Technologies (IET), Leibniz Institute for Solid State and Materials Research, 01069 Dresden, Germany.ORCID 0000-0002-3461-2318
Aline Lima GuérinTherapeutic Engineering and Bioproduction in Health Biotechnology (IBIS), Faculty of Sciences, University of Montpellier, 34095 Montpellier, France.
Mariana Souza RodriguesDepartment of Restorative Dentistry, Araraquara School of Dentistry, Sao Paulo State University (UNESP), Araraquara 14801-903, SP, Brazil.
Camila Félix da SilvaProgram in Dentistry, Department of Clinical and Social Dentistry, Federal University of Paraiba (UFPB), João Pessoa 58051-900, PB, Brazil.
Bruno Martins MacielDepartment of Restorative Dentistry, Araraquara School of Dentistry, Sao Paulo State University (UNESP), Araraquara 14801-903, SP, Brazil.ORCID 0009-0000-5764-2504
Abdulaziz AlhotanDepartment of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.ORCID 0000-0002-9036-0485
Saleh AlhijjiDepartment of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.ORCID 0000-0001-7117-2203
Marilia Mattar Amoêdo Campos VeloDepartment of Restorative Dentistry, Araraquara School of Dentistry, Sao Paulo State University (UNESP), Araraquara 14801-903, SP, Brazil.ORCID 0000-0001-7841-9459
Lúcio Roberto Cançado CastellanoProgram in Dentistry, Department of Clinical and Social Dentistry, Federal University of Paraiba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-0851-5298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to engineer nanofibrous scaffolds that prioritize architecture, rather than relying solely on the drug, to achieve reproducible, long-acting local therapies. Cotton-wool-like fiber, three-dimensional (3D) poly(L-lactic acid)/polyethene glycol (PLLA/PEG) blend scaffolds were fabricated using solution blow spinning (SBS) as a customizable encapsulation platform for controlled antibiotic release. Morphological and wettability analyses were performed by scanning electron microscopy (SEM) and pendant-drop contact angle measurements, respectively. Fiber diameters were quantified using ImageJ. The chemical composition and thermal behavior were investigated by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). In vitro, assays were conducted to assess the antimicrobial activity of vancomycin-loaded scaffolds against

Indexed as

antimicrobial activitybiocompatibilitycontrolled releasenanofibrous scaffoldsPLLA/PEG blendvancomycin

Identifiers

PMID41374803
PMCPMC12694018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.