Evidence map›Paper›PMID 41374712›Full record

ArticleSensors (Basel, Switzerland)2025

Assessment of Image Quality Performance of a Photon-Counting Computed Tomography Scanner Approved for Whole-Body Clinical Applications.

Francesca Saveria Maddaloni, Antonio Sarno, Alessandro Loria, Anna Piai, Cristina Lenardi, Antonio Esposito, Antonella Del Vecchio

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesca Saveria MaddaloniDepartment of Physics 'Aldo Pontremoli', University of Milan, 20133 Milan, Italy.ORCID 0009-0007-3331-9738
Antonio SarnoDepartment of Physics 'Aldo Pontremoli', University of Milan, 20133 Milan, Italy.ORCID 0000-0002-3034-7166
Alessandro LoriaMedical Phyisics Department, IRCCS San Raffaele Hospital, 20132 Milan, Italy.ORCID 0000-0002-3274-7008
Anna PiaiMedical Phyisics Department, IRCCS San Raffaele Hospital, 20132 Milan, Italy.ORCID 0000-0003-2126-4796
Cristina LenardiDepartment of Physics 'Aldo Pontremoli', University of Milan, 20133 Milan, Italy.
Antonio EspositoExperimental Imaging Center, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Antonella Del VecchioMedical Phyisics Department, IRCCS San Raffaele Hospital, 20132 Milan, Italy.ORCID 0000-0002-7889-7896

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhoton-counting computed tomography (PCCT) represents a major technological advance in clinical CT imaging, offering superior spatial resolution, enhanced material discrimination, and potential radiation dose reduction compared to conventional energy-integrating detector systems. As the first clinically approved PCCT scanner becomes available, establishing a comprehensive characterization of its image quality is essential to understand its performance and clinical impact.

methodsImage quality was evaluated using a commercial quality assurance phantom with acquisition protocols typically used for three anatomical regions-head, abdomen/thorax, and inner ear-representing diverse clinical scenarios. Each region was scanned using both ultra-high-resolution (UHR, 120 × 0.2 mm slices) and conventional (144 × 0.4 mm slices) protocols. Conventional metrics, including signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), slice thickness accuracy, and uniformity, were assessed following international standards. Task-based analysis was also performed through target transfer function (TTF), noise power spectrum (NPS), and detectability index (d') to evaluate diagnostic relevance.

resultsUHR protocols provided markedly improved spatial resolution, particularly in the inner ear imaging, as confirmed by TTF analysis, though with increased noise and reduced low-contrast detectability in certain conditions. CT numbers showed linear correspondence with known attenuation coefficients across all protocols.

conclusionsThis study establishes a detailed technical characterization of the first clinical PCCT scanner, demonstrating significant improvements in terms of spatial resolution and accuracy of the quantitative image analysis, while highlighting the need for noise-contrast optimization in high-resolution imaging.

Indexed as

Phantoms, ImagingTomography, X-RayWhole Body ImagingHumansImage Processing, Computer-AssistedLinear ModelsPhotonsSignal-To-Noise RatioCT image qualityphoton-counting detectorstask-based metrics

Identifiers

PMID41374712
PMCPMC12693879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.