Evidence map›Paper›PMID 41373961›Full record

ArticleNutrients2025

Nonlinear and Sex-Specific Associations of Vitamin D Metabolites with Inflammatory Blood Markers in 125,537 Adults.

Xitong Li, Xin Chen, Yvonne Liu, Jingyun Wang, Carl-Friedrich Hocher, Christoph Reichetzeder, Saban Elitok, Bernhard K Krämer, Anne Schönbunn, Cornelia Doebis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xitong LiFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.ORCID 0009-0003-3060-282X
Xin ChenFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.ORCID 0000-0003-4997-1257
Yvonne LiuFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.ORCID 0000-0002-5688-2108
Jingyun WangFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.
Carl-Friedrich HocherFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.
Christoph ReichetzederInstitute for Clinical Research and Systems Medicine, Health and Medical University, 14467 Potsdam, Germany.
Saban ElitokInstitute for Clinical Research and Systems Medicine, Health and Medical University, 14467 Potsdam, Germany.
Bernhard K KrämerFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.ORCID 0000-0002-1718-2918
Anne SchönbunnInstitute of Medical Diagnostics (IMD), 12247 Berlin, Germany.
Cornelia DoebisInstitute of Medical Diagnostics (IMD), 12247 Berlin, Germany.
Katrin HueskerInstitute of Medical Diagnostics (IMD), 12247 Berlin, Germany.
Volker von BaehrInstitute of Medical Diagnostics (IMD), 12247 Berlin, Germany.
Berthold HocherFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Center Mannheim, University of Heidelberg, 69120 Mannheim, Germany.ORCID 0000-0001-8143-0579

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is increasingly recognized as a key immunomodulatory nutrient, influencing innate and adaptive immune responses. While 25-hydroxyvitamin D [25(OH)D] is widely used to assess vitamin D status, the active form, 1,25-dihydroxyvitamin D [1,25(OH)

objectivesTo characterize the associations of 25(OH)D and 1,25(OH)

methodsWe conducted a retrospective cross-sectional analysis of 125,537 adults (37.9% male; age 18-89 years) from routine laboratory diagnostics collected between 2014 and 2020 in Germany. Serum 25(OH)D and 1,25(OH)

results

conclusionsOur findings reveal distinct, concentration-dependent associations between vitamin D metabolites and leukocyte profiles, with evidence for nonlinear and sex-specific immunological effects. Both low and high levels of 25(OH)D and 1,25(OH)

Indexed as

InflammationVitamin DAdolescentAdultAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleGermanyHumansLeukocyte CountMaleMiddle AgedNeutrophilsRetrospective Studies1,25-dihydroxyvitamin D25-hydroxyvitamin DBiomarkersVitamin D1,25-dihydroxyvitamin D [1,25(OH)2D]25-hydroxyvitamin D [25(OH)D]inflammatory blood markers

Identifiers

PMID41373961
PMCPMC12694123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.