Evidence map›Paper›PMID 41373958›Full record

ArticleNutrients2025

Gut-Protective and Multifunctional Exopolysaccharide from

Zeyuan Dong, Xinyang Li, Yaxin Wu, Zhaoyang Wang, Weitao Cui, Sishun Hu, Deshi Shi, Qi Huang, Yuncai Xiao, Hongbo Zhou and 2 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeyuan DongCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Xinyang LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Yaxin WuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Zhaoyang WangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Weitao CuiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Sishun HuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Deshi ShiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Qi HuangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Yuncai XiaoCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-0171-9693
Hongbo ZhouCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-3954-3972
Zili LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-9729-1339
Zutao ZhouCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-1007-062X

Funding

the Earmarked Fund for China Agriculture Research System CARS-41the Key Research and Development Project of Hubei Province 2021BBA252the National Key Research and Development Program of China 2023YFD1800301
6 · The paper itself

Abstract

backgroundEnteropathogenic

resultsEPS-T1, with a molecular weight of 81.21 ± 1.28 kDa, was mainly composed of glucose, galactose, rhamnose, and mannose, and exhibited a porous, sheet structure with relatively high thermal stability. In vitro, EPS-T1 (200 μg/mL) significantly inhibited EPEC growth and biofilm formation, reduced bacterial adhesion to intestinal epithelial cells, and exhibited broad-spectrum free radical scavenging activity. In vivo, EPS-T1 treatment alleviated EPEC-induced weight loss and intestinal tissue damage, reduced the intestinal EPEC load, downregulated pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), upregulated the anti-inflammatory cytokine IL-10, and improved serum antioxidant indices (T-AOC, SOD, and GSH-PX) while decreasing MDA levels.

conclusionsThese results demonstrate that EPS-T1 derived from

Indexed as

EnteritisEnterococcus faeciumEnteropathogenic Escherichia coliEscherichia coli InfectionsPolysaccharides, BacterialAnimalsAntioxidantsBacterial AdhesionBiofilmsCytokinesHumansIntestinal MucosaMaleMiceOxidative StressAntioxidantsCytokinesPolysaccharides, Bacterialantibacterial activityantibiofilm activityantioxidant activityEnterococcus faeciumenteropathogenic Escherichia coliexopolysaccharidesintestinal health

Identifiers

PMID41373958
PMCPMC12694250

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.