Evidence map›Paper›PMID 41373941›Full record

ArticleNutrients2025

Excessive Effects of Extreme Energy Levels on Lipid Metabolism in Ningxiang Pigs: Insights from Gut Microbiota and Glycerophospholipid Metabolism.

Jiayi Chen, Yongmei Wu, Jianhua He, Yaodong Wang, Min Wang, Yifei Lu, Fengming Chen, Yurong Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayi ChenHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China.ORCID 0000-0002-2015-5582
Yongmei WuHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China.
Jianhua HeCollege of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-9289-4405
Yaodong WangCollege of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-8148-1023
Min WangCollege of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China.
Yifei LuHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China.
Fengming ChenHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China.ORCID 0000-0002-2448-819X
Yurong ZhaoCollege of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-2565-0670

Funding

ESI Discipline Special Project of Changsha Medical University 2022CYY006ESI Discipline Special Project of Changsha Medical University 2022CYY023Hunan Provincial Department of Education general project 22B0894Hunan Provincial Department of Education general project 22C0674Modern Agricultural Industrial Technology System (Pig Industry) of Hunan Province and the Science and Technology Innovation Program of Hunan Province 2023JJ40085
6 · The paper itself

Abstract

objectivesThis experiment investigated the response of carcass composition, digestive function, hepatic lipid metabolism, intestinal microbiota, and serum metabolomics to excessive or restrictive dietary energy in Ningxiang pigs.

methodsA total of 36 Ningxiang pigs (210 ± 2 d, 43.26 ± 3.21 kg) were randomly assigned to three treatments (6 pens of 2 piglets each) and fed a control diet (CON, digestive energy (DE) 13.02 MJ/kg,), excessive energy diet (EE, 15.22 MJ/kg), and restrictive energy diet (RE, DE 10.84 MJ/kg), respectively.

resultsResults showed that EE significantly increased the apparent digestibility of crude protein and total energy (

conclusionsThe findings suggest RE had no obvious negative effect on carcass traits of Ningxiang pigs. Apart from exacerbated body fat deposition, EE promoted fat accumulation in the liver by up-regulating the expression of lipogenic genes. Dietary energy changes affect hepatic bile acid metabolism, which may be mediated through the glycerophospholipid metabolism pathway, as well as disturbances in the gut microbiota.

Indexed as

DietEnergy IntakeGastrointestinal MicrobiomeGlycerophospholipidsLipid MetabolismAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsDigestionLiverMaleSwineGlycerophospholipidsexcessive energygut microbiotahepatic lipid metabolismNingxiang pigrestrictive energy

Identifiers

PMID41373941
PMCPMC12693609

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.