Evidence map›Paper›PMID 41373906›Full record

ArticleInternational journal of molecular sciences2025

Dentinogenic Effect of BMP-7 on Wharton's Jelly Mesenchymal Stem Cells Cultured in Decellularized Dental Pulp.

Nur Athirah Ahmad Shuhaimi, Dalia Abdullah, Farinawati Yazid, Sook Luan Ng, Nurul Inaas Mahamad Apandi, Nur Azurah Abdul Ghani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nur Athirah Ahmad ShuhaimiDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Dalia AbdullahDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.ORCID 0000-0003-1112-6859
Farinawati YazidDepartment of Family Oral Health, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.ORCID 0000-0002-2715-4558
Sook Luan NgDepartment of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.ORCID 0000-0002-0200-086X
Nurul Inaas Mahamad ApandiDepartment of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.ORCID 0000-0002-7424-5938
Nur Azurah Abdul GhaniDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.

Funding

Ministry of Higher Education Malaysia FRGS/1/2022/SKK11/UKM/01/3
6 · The paper itself

Abstract

Decellularized tissue scaffolds mimic the native pulp-dentin microenvironment and support the odontogenic development of stem cells. This study investigated the dentinogenic effect of Wharton's Jelly Mesenchymal Stem Cells (WJMSCs) in decellularized human dental pulp (DHDP) with bone morphogenic protein-7 (BMP-7) at three concentrations: 0 ng/mL (control), 25 ng/mL, and 50 ng/mL. The effects of BMP-7 were evaluated by histological examination, WJMSC viability using AlamarBlue, dentinogenic gene expression by qPCR, and dentinogenic protein expression by ELISA. By day 21, all three groups exhibited cell distribution along the pore surfaces of DHDP, followed by the presence of a collagen matrix in the tissue. WJMSC viability treated with 25 ng/mL and 50 ng/mL showed a statistically significant increase on days 7, 14, and 21 compared to the control group (

Indexed as

Bone Morphogenetic Protein 7Dental PulpMesenchymal Stem CellsWharton JellyCell DifferentiationCells, CulturedCell SurvivalCore Binding Factor Alpha 1 SubunitDentinDentin SialophosphoproteinExtracellular Matrix ProteinsHumansOdontogenesisPhosphoproteinsSialoglycoproteinsTissue ScaffoldsBMP7 protein, humanBone Morphogenetic Protein 7Core Binding Factor Alpha 1 SubunitDentin SialophosphoproteinDMP1 protein, humanExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteinscell proliferationdentin matrix protein-1dentin sialophosphoproteinodontogenic markerregenerative endodontic therapy

Identifiers

PMID41373906
PMCPMC12693673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.