Evidence map›Paper›PMID 41373889›Full record

ArticleInternational journal of molecular sciences2025

L467F;F508del Complex Allele in a Heterozygous State with CFTRdele2,3: What to Expect from CFTR Modulators?

Elena Kondratyeva, Anna Efremova, Yuliya Melyanovskaya, Maria Krasnova, Michael Milovanov, Olga Shchagina, Anna Stepanova, Anna Voronkova, Victoria Sherman, Sergey Kutsev and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elena KondratyevaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0001-6395-0407
Anna EfremovaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0001-5035-6396
Yuliya MelyanovskayaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0002-8814-5532
Maria KrasnovaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0002-2195-3025
Michael MilovanovResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.
Olga ShchaginaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0003-4905-1303
Anna StepanovaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0003-0416-8137
Anna VoronkovaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0002-8183-7990
Victoria ShermanResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0003-2206-1528
Sergey KutsevResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0002-3133-8018
Dmitry GoldshteinResearch Centre for Medical Genetics, 1 Moskvorechye St., 115552 Moscow, Russia.ORCID 0000-0003-2438-1605

Funding

Russian Science Foundation 22-15-00473-П
6 · The paper itself

Abstract

CFTR modulators have significantly affected the prognosis for cystic fibrosis, improving the clinical course in most patients with the F508del variant and several other

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorMutationAllelesFemaleGenotypeHeterozygoteHumansMaleCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorCFTR genecomplex allelecystic fibrosisF508delintestinal current measurementintestinal organoidsL467Fpancreatitistargeted therapy

Identifiers

PMID41373889
PMCPMC12693412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.