ArticleInternational journal of molecular sciences2025
Molecular Response of Simmental Cows to Negative Energy Balance: Regulation of Interleukin-6 and Plasminogen During Early Lactation.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Integrated Metabolic, Oxidative, Inflammatory, and Mammary Health Signatures Characterize Low Body Condition Score in Dairy Cows.International journal of molecular sciences · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Negative energy balance (NEB) during early lactation links spontaneous lipolysis (SL) with inflammatory signaling, yet the molecular response in dual-purpose breeds remains insufficiently characterized. This study investigated how NEB regulates circulating concentrations of interleukin-6 (IL-6) and plasminogen (PL) in Simmental cows, contextualizing these changes within concurrent metabolic adaptation. Forty-two cows were monitored from approximately two weeks prepartum to 150 days in milk across six defined stages. Energy balance (EB) was calculated from feed intake and energy-corrected milk yield, while daily milk production (DMP), milk composition, body condition score (BCS), β-hydroxybutyrate (BHBA), glucose (GLU), leptin (LEP), selected fatty acids (FAs: C16:0, C18:0, C18:1-t9, C18:2, IL-6), and PL were determined. EB declined progressively as DMP increased (r = -0.689,
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