Evidence map›Paper›PMID 41373868›Full record

ArticleInternational journal of molecular sciences2025

The Role of Osteoblasts in Phenotypic Variability of Dominant Osteogenesis Imperfecta: Evidence from Patients and Murine Models.

Milena Jovanovic, Apratim Mitra, Chris Stephan, Ka Wai Wong, Sara Talvacchio, Antonella Forlino, Michael To, Kenneth M Kozloff, Ryan K Dale, Joan C Marini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Milena JovanovicSection on Heritable Disorders of Bone and Extracellular Matrix, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Apratim MitraBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3279-0054
Chris StephanDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4687-5481
Ka Wai WongDepartment of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen 518053, China.
Sara TalvacchioOffice of the Clinical Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0006-6969-4735
Antonella ForlinoBiochemistry Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-6385-1182
Michael ToDepartment of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen 518053, China.
Kenneth M KozloffDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Ryan K DaleBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Joan C MariniSection on Heritable Disorders of Bone and Extracellular Matrix, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Italian Ministry of Education, University and Research (MIUR) (Dipartimenti di Eccellenza [2023-2027])NICHD IRP funding ZIA HD008830-16
6 · The paper itself

Abstract

One of the hallmarks of Osteogenesis Imperfecta (OI) is phenotypic variability among individuals with the same mutation. The aim of our study is to investigate the under-explored role of osteoblast differentiation in OI phenotypic variability by using human and murine OI osteoblasts. This is the first comparative study of osteoblasts from OI patients vs. healthy pediatric controls. We investigated osteoblasts carrying

Indexed as

OsteoblastsOsteogenesis ImperfectaAnimalsCell DifferentiationChildChild, PreschoolCollagen Type ICollagen Type I, alpha 1 ChainDisease Models, AnimalFemaleHumansMaleMiceMitochondriaMutationPhenotypeCOL1A1 protein, humanCollagen Type ICollagen Type I, alpha 1 Chainbone mineralizationmitochondriaosteoblast differentiationOsteogenesis Imperfectaphenotypic variability

Identifiers

PMID41373868
PMCPMC12692505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.