The Cellular Effects of Di(2-ethylhexyl) Phthalate in Non-Malignant Colonic Epithelia Involve Oxidative Stress.

Zachary S Bomstein, Kimberly F Allred, Clinton D Allred

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zachary S BomsteinDepartment of Nutrition, University of North Carolina at Greensboro, 319 College Ave., Greensboro, NC 27412, USA.

Kimberly F AllredDepartment of Nutrition, University of North Carolina at Greensboro, 319 College Ave., Greensboro, NC 27412, USA.

Clinton D AllredDepartment of Nutrition, University of North Carolina at Greensboro, 319 College Ave., Greensboro, NC 27412, USA.

Funding

NIEHS NIH HHS R56-ES033052

6 · The paper itself

Abstract

Human exposure to Di(2-ethylhexyl) Phthalate (DEHP) occurs through ingestion of contaminated food. Yet, the effects of DEHP on gastrointestinal toxicity at the cellular level are poorly understood and studies conducted to date have used malignant cell lines, limiting our understanding of molecular signaling in intestinal epithelia of otherwise healthy individuals. The objective of our study was to use a non-transformed, colonic epithelial cell line (Young Adult Mouse Colonocytes; YAMCs) to characterize the in vitro effects of DEHP on non-malignant colonic epithelia. A 72 h DEHP exposure significantly reduced cell number and proliferation while short-term exposure increased: cellular apoptosis,

Indexed as

ColonDiethylhexyl PhthalateEpithelial CellsIntestinal MucosaOxidative StressAnimalsApoptosisCell LineCell ProliferationHumansMiceReactive Oxygen SpeciesReceptors, Aryl HydrocarbonDiethylhexyl PhthalateReactive Oxygen SpeciesReceptors, Aryl Hydrocarbonaryl hydrocarbon receptor (AhR)colonocytesDi(2-ethylhexyl) phthalate (DEHP)nuclear factor erythroid 2-related factor 2 (Nrf2)oxidative stress

Identifiers

PMID41373866

DOI10.3390/ijms262311716

PMCPMC12692327

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.