Evidence map›Paper›PMID 41373844›Full record

ArticleInternational journal of molecular sciences2025

Downregulation of the CCK-B Receptor in Pancreatic Stellate Cells Blocks Molecular Proliferative Pathways and Increases Apoptosis to Decrease Pancreatic Cancer Growth In Vitro.

Miranda Ortega, Eri Agena, Wenqiang Chen, Hong Cao, Sona Vasudevan, Narayan Shivapurkar, Mariaelena Pierobon, Jill P Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miranda OrtegaDepartments of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20007, USA.
Eri AgenaDepartments of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20007, USA.
Wenqiang ChenDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.ORCID 0009-0006-6864-9932
Hong CaoDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.
Sona VasudevanDepartments of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0002-1882-7909
Narayan ShivapurkarDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.
Mariaelena PierobonCenter for Applied Proteomics and Molecular Medicine, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Jill P SmithDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0002-0835-4802

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
The CCK-B receptor signaling pathway as a driver of pancreatic cellular plasticity and carcinogenesisR01CA277680 · NCI · GEORGETOWN UNIVERSITY · PI Jill P Smith · 2023 to 2026
$2.4M
NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA277680NIH HHS 1C06CA277680-25
6 · The paper itself

Abstract

Pancreatic cancer is characterized by an extensive fibrotic stroma largely driven by activated pancreatic stellate cells (PSCs)/fibroblasts, which also function to support tumor growth and metastasis. Cholecystokinin-B receptors (CCK-BRs) are expressed on pancreatic stellate cells (PSCs) and have emerged as a key regulator of PSC activation and tumor-stromal interactions. We hypothesized that disrupting CCK-BR function shifts PSCs to a more quiescent phenotype and reduces their pro-fibrotic and tumor-supportive activity to decrease growth of pancreatic cancer. Murine PSCs were genetically engineered with CRISPR-

Indexed as

ApoptosisPancreatic NeoplasmsPancreatic Stellate CellsReceptor, Cholecystokinin BAnimalsCell Line, TumorCell MovementCell ProliferationCoculture TechniquesDown-RegulationGene Expression Regulation, NeoplasticHumansMiceProglumideSignal TransductionProglumideReceptor, Cholecystokinin Bcancer-associated fibroblastmolecular signaling pathwaystumor microenvironment

Identifiers

PMID41373844
PMCPMC12691738

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.