ArticleInternational journal of molecular sciences2025
Quantifying the Activation Barrier for Phospholipid Monolayer Fusion Governing Lipid Droplet Coalescence.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Special Issue "The Role of Lipids in Health and Diseases".International journal of molecular sciences · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Lipid droplet (LD) coalescence is a critical cellular process that reshapes lipid storage, drives metabolic disease progression, and dictates the stability of LD-mimetic drug carriers. However, the rate-limiting step-fusion of the phospholipid monolayers surrounding neutral-lipid cores-remains poorly quantified compared to bilayer fusion. Here, we quantitatively determine the activation barrier for LD coalescence by tracking the kinetics in protein-free adiposome models. Using a multi-technique approach combining time-resolved dynamic light scattering and small-angle X-ray scattering, we reveal that monolayer fusion is the kinetic bottleneck. We demonstrate that lipid composition is a powerful regulator of this barrier: cone-shaped lipids (e.g., dioleoylphosphatidylethanolamine) lower the barrier and promote fusion, while phosphatidylcholine-rich monolayers enhance stability. A continuum fusion model, adapted for curved monolayers, explains these results through changes in spontaneous curvature, hydration repulsion, and stalk energetics. Our findings establish composition-dependent design rules for controlling LD dynamics in metabolic health and for engineering stable or triggerable lipid-based delivery vehicles.
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