ArticleInternational journal of molecular sciences2025
The Tetrapeptide HAEE Promotes Amyloid-Beta Clearance from the Brain.
Kristina A Mukhina, Kseniya B Varshavskaya, Aleksandra D Rybak, Viktor V Grishchenko, Elena V Kuzubova, Mikhail V Korokin, Olga I Kechko, Vladimir A Mitkevich
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Kristina A MukhinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Kseniya B VarshavskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Aleksandra D RybakEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Viktor V GrishchenkoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Elena V KuzubovaResearch Institute of Pharmacology of Living Systems, Belgorod State National Research University, 85 Pobedy St., 308015 Belgorod, Russia.
Mikhail V KorokinResearch Institute of Pharmacology of Living Systems, Belgorod State National Research University, 85 Pobedy St., 308015 Belgorod, Russia.ORCID 0000-0001-5402-0697
Olga I KechkoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Vladimir A MitkevichEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Funding
Ministry of Science and Higher Education of the Russian Federation (the Federal Scientific-technical Programme for Genetic Technologies Development for 2019-2030) agreement N◦ 075-15-2025-558
6 · The paper itself
Abstract
Alzheimer's disease is characterized by the accumulation of neurotoxic forms of amyloid-beta (Aβ) in the brain, leading to synaptic dysfunction, neuroinflammation, and neuronal death. The tetrapeptide HAEE crosses the blood-brain barrier (BBB), inhibits the formation of toxic Aβ oligomers, and reduces amyloid burden
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
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