Development and Application of Visible-Light-Responsive Perylene Diimide Functionalized Silk Fibroin/Polylactic Acid Antibacterial Nanofibrous Membranes.

Sheng Lv, Hongyu Lin, Ying Lin, Qingyan Peng, Yuyang Song, Xiaodong Tan, Xiao Yang, Shixiong Yi

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Sheng LvState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Hongyu LinState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Ying LinState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Qingyan PengState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Yuyang SongState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Xiaodong TanState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0002-8940-0160

Xiao YangState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Shixiong YiState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0002-7234-9709

Funding

Fundamental Research Funds for the Central Universities No. SWU-KW22004National Natural Science Foundation of China No. 22008201Natural Science Foundation Innovation and Development Joint Fund Project of Chongqing No. CSTB2023NSCQ-LZX0028Natural Science Foundation of Chongqing No. CSTB2024NSCQ-MSX0680

6 · The paper itself

Abstract

The issue of antibiotic resistance is becoming increasingly severe, urgently requiring the development of new antibacterial strategies. Photodynamic therapy (PDT) has gradually emerged as a promising alternative due to its spatiotemporal controllability, low risk of drug resistance, and broad-spectrum antibacterial properties. However, most existing photosensitizers (PSs) are hydrophobic, which limits their application efficiency in PDT. To address this problem, we designed and synthesized a water-soluble perylene diimide derivative (PDICN-CBn) as a photosensitizer. By introducing quaternary ammonium salt groups, its water solubility was improved, and antibacterial activity was enhanced. Subsequently, PDICN-CBn was assembled into silk fibroin/polylactic acid (SF/PLA) nanofibrous membranes via electrospinning technology, successfully constructing a visible-light-responsive ternary composite nanofibrous membrane (SF/PLA@PDICN-CBn). Using various characterization methods such as nuclear magnetic resonance (

Indexed as

Anti-Bacterial AgentsFibroinsImidesNanofibersPerylenePolyestersEscherichia coliLightMembranes, ArtificialMicrobial Sensitivity TestsPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesStaphylococcus aureusAnti-Bacterial AgentsFibroinsImidesMembranes, ArtificialPeryleneperylenediimidePhotosensitizing AgentsPolyesterspoly(lactide)Reactive Oxygen Speciesantibacterialelectrospinningperylene diimide derivativephotodynamic therapy

Identifiers

PMID41373688

DOI10.3390/ijms262311533

PMCPMC12691820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.