Evidence map›Paper›PMID 41373660›Full record

ArticleInternational journal of molecular sciences2025

Neuroprotective and Antioxidant Properties of Different Novel Steroid-Derived Nitrones and Oximes on Cerebral Ischemia In Vitro.

Sara Izquierdo-Bermejo, Mourad Chioua, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara Izquierdo-BermejoDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.ORCID 0009-0003-7491-7313
Mourad ChiouaLaboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
Dimitra Hadjipavlou-LitinaDepartment of Pharmaceutical Chemistry, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-1844-350X
Francisco López-MuñozFaculty of Health Sciences-HM Hospitals, Camilo José Cela University, Villafranca del Castillo, 28692 Madrid, Spain.ORCID 0000-0002-5188-6038
José Marco-ContellesLaboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
María Jesús Oset-GasqueDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.ORCID 0000-0002-7223-0222

Funding

Spanish Ministry of Economy and Competitiveness SAF2015-65586-RUniversidad Camilo José Cela (UCJC) UCJC-NENs, UCJC-CHONICEN,UCJC- HDACi-ICTUS
6 · The paper itself

Abstract

Despite the substantial global impact of ischemic stroke, current therapeutic options remain limited and only partially effective. To advance neuroprotective strategies that could improve the safety and efficacy of existing treatments while preserving brain tissue, we synthesized and evaluated seven new nitrones (

Indexed as

AntioxidantsBrain IschemiaNeuroprotective AgentsNitrogen OxidesOximesSteroidsAnimalsCell SurvivalHumansRatsAntioxidantsNeuroprotective AgentsNitrogen OxidesnitronesOximesSteroidscerebral ischemianeuroactive steroidsneuroprotectionnitronesoxidative stressoximesstroke

Identifiers

PMID41373660
PMCPMC12692713

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.