Evidence map›Paper›PMID 41373535›Full record

ArticleInternational journal of molecular sciences2025

John C Bladen, Jun Wang, Mariya Moosajee, Muhammad Rahman, Ajanthah Sangaralingam, Vijay K Gogna, Claude Chelala, Edel A O'Toole, Michael P Philpott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John C BladenCentre for Cell Biology and Cutaneous Research, Blizard Institute, London E1 2AT, UK.ORCID 0000-0002-9263-8006
Jun WangCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6AU, UK.ORCID 0000-0003-2509-9599
Mariya MoosajeeDepartment of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London EC1V 9EL, UK.ORCID 0000-0003-1688-5360
Muhammad RahmanCentre for Cell Biology and Cutaneous Research, Blizard Institute, London E1 2AT, UK.
Ajanthah SangaralingamCentre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London EC1M 6AU, UK.
Vijay K GognaCentre for Cell Biology and Cutaneous Research, Blizard Institute, London E1 2AT, UK.
Claude ChelalaCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6AU, UK.
Edel A O'TooleCentre for Cell Biology and Cutaneous Research, Blizard Institute, London E1 2AT, UK.
Michael P PhilpottCentre for Cell Biology and Cutaneous Research, Blizard Institute, London E1 2AT, UK.

Funding

Cancer Research UK Centre of Excellence Award to Barts Cancer Centre C16420/A18066Fight For Sight Fellowship 1327/28
6 · The paper itself

Abstract

Morphoeic basal cell carcinoma (mBCC) has a higher risk of local recurrence than the more indolent nodular (nodBCC) subtype. Little is known about the genetic and molecular makeup of mBCC that determines its invasive behaviour: a comparison of mBCC with nodBCC was carried out. Whole-exome sequencing (WES) of 20 BCC tumours (10 eyelid morphoeic and 10 nodular) underwent driver gene detection using OncodriveFM and MutSigCV, followed by a randomisation analysis procedure. Samples underwent RNA sequencing, gene-set enrichment analysis and candidates verified by RT-PCR.

Indexed as

Basal Cell CarcinomaEyelid NeoplasmsSkin NeoplasmsZinc Finger Protein Gli2AgedAged, 80 and overCell Line, TumorExome SequencingFemaleGene Expression Regulation, NeoplasticHedgehog ProteinsHumansMaleMiddle AgedMutationNuclear ProteinsGLI2 protein, humanHedgehog ProteinsNuclear ProteinsPatched-1 ReceptorZinc Finger Protein Gli2basal cell carcinomaFLNBGLI2hedgehog signallingmorphoeicultraviolet

Identifiers

PMID41373535
PMCPMC12692270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.