ArticleInternational journal of molecular sciences2025
Epithelial-Mesenchymal Transition Increases the Susceptibility of Human A549 Cells to Nanosecond Pulsed Electric Fields.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nanosecond pulsed electric fields (nsPEFs) are ultrashort, high-intensity electrical pulses that have unique biological actions, including the formation of membrane nanopores and the efficient induction of cell death. nsPEFs are currently regarded as a promising modality for cancer therapy. During cancer progression, abnormal cells become more malignant through epithelial-mesenchymal transition (EMT). EMT is a biological process in which cells acquire mesenchymal traits and thereby increase their motility and invasiveness. Despite the importance of EMT in cancer progression, however, limited information is available on whether EMT modulates cellular responses to nsPEFs. In this study, we compared the responses of EMT and non-EMT human A549 cells to nsPEFs. We found that EMT induction rendered A549 cells more susceptible to nsPEFs as evidenced by decreased cell viability and increased nanopore formation upon nsPEF exposure. nsPEFs predominantly induced non-apoptotic cell death in EMT cells, and extracellular Ca
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