Evidence map›Paper›PMID 41373515›Full record

ArticleInternational journal of molecular sciences2025

Molecular Studies of

Natalia Petri, Angeliki Margoni, Konstantinos Droutsas, Andriana Diamantopoulou, Nikolaos Kappos, Athanasios G Papavassiliou, Marilita M Moschos, Christos Kroupis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia PetriDepartment of Clinical Biochemistry, 'Attikon' University General Hospital, Medical School, National and Kapodistrian University of Athens, Chaidari, 12462 Athens, Greece.
Angeliki MargoniDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0009-0007-0798-6262
Konstantinos DroutsasFirst Department of Ophthalmology, 'G. Gennimatas' General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Andriana DiamantopoulouDepartment of Clinical Biochemistry, 'Attikon' University General Hospital, Medical School, National and Kapodistrian University of Athens, Chaidari, 12462 Athens, Greece.
Nikolaos KapposFirst Department of Ophthalmology, 'G. Gennimatas' General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Athanasios G PapavassiliouDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0001-5803-4527
Marilita M MoschosFirst Department of Ophthalmology, 'G. Gennimatas' General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Christos KroupisDepartment of Clinical Biochemistry, 'Attikon' University General Hospital, Medical School, National and Kapodistrian University of Athens, Chaidari, 12462 Athens, Greece.ORCID 0000-0002-5876-2599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-onset Fuchs endothelial corneal dystrophy (FECD) is a hereditary, progressive, bilateral and irreversible disorder that is characterized by thickening of Descemet's membrane, microscopic collagenous protuberances known as guttae, and accelerated loss of corneal endothelial cells. Patients initially complain of blurred vision, and as the disease progresses, painful epithelial edema develops. Untreated cases of FECD often result in blindness, and then, the only treatment is corneal transplantation. DNA polymorphisms in many genes have been implicated, among them

Indexed as

Fuchs' Endothelial DystrophyTranscription Factor 4AgedAged, 80 and overAge of OnsetAlgorithmsCase-Control StudiesCost-Benefit AnalysisFemaleGenetic Predisposition to DiseaseGreeceHumansMaleMiddle AgedPolymorphism, Single NucleotideTrinucleotide Repeat ExpansionTCF4 protein, humanTranscription Factor 4FECDgenetic profilemolecular diagnosisprognostic markersSNPTCF4 genetrinucleotide repeat expansion

Identifiers

PMID41373515
PMCPMC12692371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.