Evidence map›Paper›PMID 41373498›Full record

ArticleInternational journal of molecular sciences2025

Computational Analysis of GAT1 Mutations: Functional Consequences from Molecular Dynamics and Binding Free Energy Calculations.

Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Jongseon Choe, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad YasirDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Jinyoung ParkDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.ORCID 0009-0008-7662-5601
Eun-Taek HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Won Sun ParkDepartment of Physiology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Jin-Hee HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-0836-6675
Jongseon ChoeDepartment of Microbiology and Immunology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.ORCID 0000-0002-0424-1667
Mubashir HassanThe Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Andrzej KloczkowskiThe Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-1002-5095
Wanjoo ChunDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-1984-3545

Funding

National Research Foundation of Korea RS-2025-23323186Regional Innovation System & Education (RISE) program 2025-RISE-10-002
6 · The paper itself

Abstract

GABA transporter 1 (GAT1), encoded by the

Indexed as

GABA Plasma Membrane Transport ProteinsMolecular Dynamics SimulationMutationHumansHydrogen BondingProtein BindingProtein ConformationThermodynamicsGABA Plasma Membrane Transport ProteinsSLC6A1 protein, humanepilepsyGAT1GAT1 mutationsgmx_MMPBSAmolecular dynamics simulationtiagabine

Identifiers

PMID41373498
PMCPMC12692106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.