ArticleInternational journal of molecular sciences2025
Identification of Fibrillarin and Cajal Bodies Under DNA Replication Stress Conditions in Root Meristem Cells of
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The correct course of DNA replication is crucial to maintaining the integrity of the genome. Any abnormality in this process inevitably leads to replication stress (RS). Hydroxyurea (HU) is a replication stressor widely used to inhibit DNA biosynthesis by depleting the deoxyribonucleoside triphosphate (dNTP) pool. The aim of the study was to examine how the 24-, 48-, and 72 h exposures to 0.75 mM HU affect the localization of fibrillarin (FBL; a highly conserved nucleolar protein and the component of Cajal bodies) and the amount of rRNA transcripts (detected using 5-ethynyl uridine; 5-EU), in root meristem cells of
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