ArticleInternational journal of molecular sciences2025
Increased Expression of TRPV1 in the Central Nucleus of the Amygdala Is Involved in Orthodontic Pain in Rats.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Upregulation of AIM2 in the Central Nucleus of the Amygdala Correlates with Pain Induced by Tooth Movement.International journal of molecular sciences · 2026Article
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10 authors.
Funding
Abstract
Transient receptor potential vanilloid type 1 (TRPV1) is known to gate nociceptive signals, while the central amygdala (CeA) plays a key role in encoding pain and avoidance behaviors; however, whether TRPV1 within CeA mediate orthodontic tooth-moving pain remains unclear. To investigate this, we examined the role of TRPV1 in the CeA using a rat model of experimental tooth movement. A total of 118 Sprague-Dawley rats were divided into control, 30 g, 50 g, and 80 g force groups. Micro-CT confirmed successful tooth movement, and the 50 g force was selected as optimal. Pain was assessed by mechanical hypersensitivity using the von Frey test, face-grooming, and the Rat Grimace Scale (RGS). All measures showed maximal changes at day 1 and returned to baseline by day 7. Immunohistochemistry and western blot analysis in the 50 g group revealed upregulation of TRPV1 in the CeA following force application, a trajectory that paralleled the pain behavioral responses. These findings indicate that experimental tooth movement upregulates TRPV1 in the CeA and that this channel contributes to orthodontic pain.
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