Evidence map›Paper›PMID 41373429›Full record

ArticleInternational journal of molecular sciences2025

Photodynamic Inactivation Enhances Antibiotic Efficacy Without Affecting Drug Stability: Insights into Photosensitizer-Antibiotic Combination Therapies.

Rocío B Acosta, Edgardo N Durantini, Mariana B Spesia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rocío B AcostaIDAS-CONICET, Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta Nacional 36 Km 601, Río Cuarto X5804BYA, Córdoba, Argentina.
Edgardo N DurantiniIDAS-CONICET, Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta Nacional 36 Km 601, Río Cuarto X5804BYA, Córdoba, Argentina.ORCID 0000-0001-8901-7543
Mariana B SpesiaIDAS-CONICET, Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta Nacional 36 Km 601, Río Cuarto X5804BYA, Córdoba, Argentina.ORCID 0000-0002-7471-8950

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PPI N° 11220220100627
6 · The paper itself

Abstract

Photodynamic inactivation (PDI) represents a promising strategy to overcome bacterial resistance by combining light, oxygen, and a photosensitizer (PS) to generate reactive oxygen species (ROS) that damage essential cellular components. Combining PDI with conventional antibiotics (ATBs) may further enhance bacterial eradication through complementary mechanisms. In this study, the tetracationic 5,10,15,20-tetra(4-

Indexed as

Anti-Bacterial AgentsPhotochemotherapyPhotosensitizing AgentsAmpicillinDrug StabilityEscherichia coliLightMicrobial Sensitivity TestsPorphyrinsRifampinStaphylococcus aureusAmpicillinAnti-Bacterial AgentsPhotosensitizing AgentsPorphyrinsRifampinantibioticsantimicrobialbacteriacationic porphyrincombination therapiesEscherichia coliphotodynamic inactivationStaphylococcus aureus

Identifiers

PMID41373429
PMCPMC12692489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.