ArticleWorld journal of surgical oncology2025
Circ_0001741 regulates proliferation and invasion in ESCC via the miR-194-5p/E2F3 axis.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeEsophageal squamous cell carcinoma (ESCC) is a highly aggressive gastrointestinal malignancy. This study aims to investigate the role and molecular mechanism of a novel circular RNA, circ_0001741, in ESCC progression.
methodsThe circular structure of circ_0001741 was confirmed by RNase R and actinomycin D assays alongside divergent primer-based amplification targeting its backsplice junction (BSJ). Its expression was profiled using an ESCC tissue microarray. Functional effects of circ_0001741 on proliferation and invasion were assessed using CCK-8 and Transwell assays. The interactions within the circ_0001741/miR-194-5p/E2F3 axis were validated through dual-luciferase reporter, RNA pull-down, and rescue experiments.
resultsCirc_0001741 was significantly upregulated in ESCC tissues with a 7.5-fold increase compared to adjacent normal tissues. Functional assays demonstrated that silencing circ_0001741 markedly inhibited ESCC cell proliferation and invasion significantly. Mechanistically, circ_0001741 directly sponged miR-194-5p, leading to the upregulation of its target oncogene E2F3. Crucially, the anti-tumor effects induced by circ_0001741 knockdown were significantly reversed by co-silencing miR-194-5p or overexpressing E2F3, thus establishing a functional circ_0001741/miR-194-5p/E2F3 axis in ESCC.
conclusionOur findings establish that circ_0001741 drives ESCC progression by modulating the miR-194-5p/E2F3 axis, underscoring its therapeutic potential for ESCC treatment.
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