ArticleBMC pregnancy and childbirth2025
Association of maternal endometriosis with autism spectrum disorder in offspring: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundWith the increasing incidence of autism spectrum disorder (ASD), various risk factors for ASD have been identified. Among them, maternal immune activation (MIA), which can be triggered by inflammation via elevated proinflammatory cytokines, has recently been reported as a risk factor for ASD in offspring.
objectivesWe assessed the association of maternal endometriosis, a chronic gynecological inflammation that may induce MIA, with ASD in offspring. STUDY
designIn this retrospective cohort study, we used the data from a large-scale public health insurance database across Japan to identify dyads of mothers and their firstborn children, delivered between January 2005 and May 2022. Mothers with multiple pregnancies were excluded. The proportions of children diagnosed with ASD at 3 years old were compared between eligible mothers with endometriosis and those without a diagnosis of endometriosis prior to delivery. Multivariable logistic regression analysis was performed to evaluate the association of maternal endometriosis with ASD in children, after adjusting for maternal and peripartum characteristics.
resultsWe identified 30,020 eligible dyads of mothers and their firstborn children. Among them, 3,496 mothers had endometriosis. The proportions of ASD in the offspring of the group of mothers without and with endometriosis were 2.7% (720/26,524) and 2.9% (102/3,496), respectively. Logistic regression analysis revealed no significant association of maternal endometriosis with ASD in their children (adjusted odds ratio, 1.04; 95% confidence interval, 0.84–1.29).
conclusionNo significant association of maternal endometriosis with ASD in offspring was detected in this study. These findings suggest children whose mothers have an antepartum history of endometriosis alone may not need to be closely monitored for ASD, and health care providers or people involved with children may need to consider other reported backgrounds related to ASD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.