Evidence map›Paper›PMID 41372887›Full record

ArticleCancer cell international2025

Polysaccharides from Huaier induce autophagy-dependent ferroptosis to inhibit breast cancer stem cells in triple-negative breast cancer.

Linxi Zhou, Ziwei Wu, Kefei Luo, Hong Zheng, Yuan Tian, Qinwen Pan, Wenting Yan, Jun Jiang, Lingmi Hou, Minghao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linxi Zhou *Department of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China.
Ziwei Wu *Department of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China.
Kefei Luo *Department of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China.
Hong ZhengDepartment of Thoracic Surgery, Army Medical University Xinqiao Hospital, Chongqing, China.
Yuan TianDepartment of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China.
Qinwen PanDepartment of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China.
Wenting YanDepartment of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China.
Jun JiangDepartment of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China. jcbd@medmail.com.cn.
Lingmi HouDepartment of Academician (expert) Workstation, Biological Targeting Laboratory of Breast Cancer, Breast and Thyroid Surgery, Affiliated Hospital of North Sichuan Medical College, No.1 Maoyuan south road, Nanchong, 637000, Sichuan, China. houlingmi@163.com.
Minghao WangDepartment of Breast and Thyroid Surgery, Southwest Hospital of Army Medical University, No. 30 Gaotanyanzheng Street, Chongqing, 400038, China. minghaowang_swh@163.com.

Funding

Military Key Clinical Specialty 41561Z23612National Natural Science Foundation of China 82474127 and 82203057Natural Science Foundation of Chongqing CSTB2023NSCQ-MSX0520
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a highly aggressive subtype with poor prognosis and limited treatment options, largely due to the presence of breast cancer stem cells (BCSCs) that contribute to chemotherapy resistance, metastasis, and relapse. In this study, we investigated the therapeutic potential of polysaccharides from Huaier (PS-T) in targeting BCSCs via a novel mechanism involving autophagy-dependent ferroptosis. We first identified a 17-gene stemness signature from TCGA data of 167 TNBC patients, which correlated with poor prognosis. Using this signature, we developed a prognostic model that demonstrated strong predictive power for TNBC survival. In vitro, PS-T treatment significantly reduced the stemness markers POU5F1, SOX2, and NANOG, and decreased the ALDH

Indexed as

AutophagyBreast cancer stem cellsFerroptosisGPX4PS-TTriple-negative breast cancer

Identifiers

PMID41372887
PMCPMC12801537

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.