ArticleBMC pregnancy and childbirth2025
Impact of assisted reproductive therapy on kidney and pregnancy outcomes in women with early-stage chronic kidney disease: a longitudinal analysis.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLimited clinical research has focused on women with chronic kidney disease (CKD) undergoing assisted reproductive technology (ART). We aim to investigate the kidney outcome and the adverse pregnancy-related outcomes of CKD women after pregnancy with ART.
methodsA longitudinal study was conducted, including CKD and non-CKD women who had successful delivered after ART between January 2014 to December 2023. By matching with age and BMI, an optimal full-matching propensity score analysis was performed to select the optimal patients of control at a ratio of 1 to 3. Clinical and laboratory data at the baseline and during the follow-up was collected. The study had received approval from the Ethics Review Board of Sun Yat-sen Memorial Hospital (No. SYSKY-2023-008-01).
resultsNineteen CKD women and fifty-seven non-CKD women were included. Before pregnancy, glomerular hematuria (15/19, 78.9%) represented the most common clinical manifestation of the CKD women, while four (21.1%) patients appeared with proteinuria. Pre-existing hypertension occurred in one CKD women (1/19, 5.3%). Meanwhile, most of the patients (18/19, 94.7%) were in stage 1 of CKD and the rest one was in stage 2. No increased risks of ovarian hyperstimulation syndrome, kidney function deterioration, adverse maternal outcomes and adverse neonatal outcomes were observed in CKD group compared with the control.
conclusionsBased on our findings, ART appears to be as safe for women with early-stage CKD and low risk of disease progression, in terms of pregnancy complications and kidney function, as it is for the general female population.
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