ArticleBMC infectious diseases2025
Head trauma complicated with multi-site infections of Ureaplasma urealyticum and Mycoplasma hominis: a case report.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMycoplasma hominis and Ureaplasma urealyticum are genitourinary colonizers that can cause extragenital infection after trauma or surgery, yet diagnosis is frequently delayed by negative routine cultures. CASE PRESENTATION: A 60-year-old man developed persistent postoperative infection after decompressive craniotomy for head trauma. Routine cultures were non-informative. Guided by a stepwise protocol (targeted sampling of blood/cerebrospinal fluid (CSF)/wound and urethral reservoir), we detected M. hominis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)/culture and confirmed disseminated U. urealyticum by species-specific qPCR (multiple sites except CSF). Targeted therapy (doxycycline with levofloxacin) led to clinical resolution.
conclusionsIn ICU trauma or postoperative patients with culture-negative infection despite β-lactams, targeted testing for mollicutes, combining mycoplasma and ureaplasma culture, MALDI-TOF MS, and species-specific qPCR, can expedite diagnosis and guide effective therapy. CLINICAL TRIAL NUMBER: Not applicable.
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