Evidence map›Paper›PMID 41372783›Full record

ArticleHealth research policy and systems2025

Towards "Zero by 30", the Kenyan case: a systematic exploration of barriers to rabies policy implementation through systems thinking.

Laurent Smets, Sanjeet Kumar Jaiswar, Valentijn Stienen, Benedict Mueke Muma, Vincent Okungu, Nico Vandaele, Catherine Decouttere

Abstract read
In one paragraph

Article in Health research policy and systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Laurent SmetsAccess-to-Medicines Research Centre, Faculty of Economics and Business, KU Leuven, Leuven, Belgium. laurent.smets@kuleuven.be.
Sanjeet Kumar JaiswarAccess-to-Medicines Research Centre, Faculty of Economics and Business, KU Leuven, Leuven, Belgium.
Valentijn StienenAccess-to-Medicines Research Centre, Faculty of Economics and Business, KU Leuven, Leuven, Belgium.
Benedict Mueke MumaDepartment of Health Services, Government of Makueni County, Makueni, Kenya.
Vincent OkunguKenyatta National Hospital (KNH), Faculty of Health Sciences, Department of Public & Global Health, University of Nairobi, Nairobi, Kenya.
Nico VandaeleAccess-to-Medicines Research Centre, Faculty of Economics and Business, KU Leuven, Leuven, Belgium.
Catherine DecouttereAccess-to-Medicines Research Centre, Faculty of Economics and Business, KU Leuven, Leuven, Belgium.

Funding

KU Leuven C24M/19/006
6 · The paper itself

Abstract

introductionRabies is a neglected tropical disease (NTD) that disproportionately affects marginalized communities, despite the availability of effective vaccines. In response, the "Zero by 30" global strategic plan aims to eliminate dog-mediated human rabies deaths by 2030. However, localized barriers such as underreporting, fragmented vaccine supply and insufficient governance often impede progress, particularly for settings in Kenya.

methodsTo address these complexities, we employed qualitative system dynamics and group model building (GMB). We combined data from expert interviews (34 participants), field observations (five locations), and GMB workshop discussions (20 participants) to identify the feedback loops that link surveillance capacity, effective vaccinations, trust, prioritization and budget allocations in Kenya's health and veterinary sectors. This approach allowed us to map the interdependencies that lie at the basis of rabies persistence and to pinpoint systemic entry points for policy intervention. This study followed the Consolidated Criteria for Reporting Qualitative Research (COREQ) to document the methods.

resultsOur findings reveal multiple reinforcing and balancing loops involving vaccine accessibility, surveillance capacity and workforce readiness. Underreporting, budget deficits and the risk of so-called success-induced reductions in vigilance repeatedly surfaced as key impediments. Additionally, economic considerations (for example, high out-of-pocket costs and reliance on donor funds) undermine sustained rabies-control efforts. These dynamics directly intersect with the "Zero by 30" objectives, highlighting the need for stable, multiyear funding, cross-sectoral collaboration and innovative vaccination strategies (for example, streamlined pre-exposure prophylaxis regimens).

conclusionsStakeholder-validated causal-loop diagrams show that Kenya's rabies-control bottlenecks - such as vaccine stock-outs, fragmented surveillance and fluctuating political will - form self-reinforcing cycles that stall progress toward "Zero by 30". By exposing these dynamics, the study identifies policy entry-points that can break the cycles - shifting the conversation from what fails to why it persists. Therefore, the study offers decision-makers a structured systems map for turning systemic insights into effective, context-specific action.

Indexed as

Dog DiseasesHealth PolicyRabiesRabies VaccinesAnimalsDogsHumansKenyaNeglected DiseasesPolicy MakingQualitative ResearchSystems AnalysisVaccinationRabies VaccinesAccessRabiesSustainabilitySystemsVaccines

Identifiers

PMID41372783
PMCPMC12802003

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.