Trial reportBMC oral health2025
High-frequency intraoral ultrasonography for periodontal tissue characterization: a pilot study exploring echogenic signatures and inflammation detection.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05809427 (High Frequency Intraoral Ultrasound Probe for Early Diagnosis of Periodontal Diseases), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High Frequency Intraoral Ultrasound Probe for Early Diagnosis of Periodontal Diseases
Who cites it
2 citing papers in PubMed.
- A preliminary study on the radiomic assessment of the surrounding trabecular bone microenvironment in taurodontism: Is it more than a dental anomaly?BMC oral health · 2026Article
- Ultrasound-based assessment of peri-implant mucosal thickness: an ex vivo comparative study with artificial intelligence-assisted image analysis.BMC oral health · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the feasibility and diagnostic potential of high-frequency intraoral ultrasonography for the real-time evaluation and characterization of periodontal tissues, including tissue echogenicity under both healthy and inflammatory conditions. Building on our prior preclinical validation of ultrasound for pocket depth measurement in a porcine model, this pilot study provides the first human application, focusing on a novel echogenicity-based 'atlas' for differentiating healthy and inflammatory periodontal tissues.
methodsThis prospective single-center pilot study included 13 patients diagnosed with periodontitis. Each participant underwent a standardized examination combining high frequency ultrasonographic imaging (20 MHz). A total of 1,987 ultrasonic ultrasonography measurements were recorded. Ultrasonographic images were analyzed using ImageJ to assess the mean and standard deviation of pixel intensity across several periodontal tissue types. Statistical analyses included Kruskal-Wallis testing, linear discriminant analysis (LDA), and K-means clustering to explore echogenicity-based tissue differentiation.
resultsUltrasound imaging enabled visualization of periodontal structures (enamel, cementum, alveolar bone, connective tissue, inflammatory tissue). Mean echogenicity values differed significantly across tissue types (p < 0.001), with enamel showing the highest mean pixel intensity (200 ± 15) and inflammatory tissue the lowest (50 ± 10). LDA achieved partial tissue separation, while K-means clustering identified six distinct echogenicity-based clusters. Real-time imaging detected subgingival calculus and deep tissue inflammation in 8 of 13 patients.
conclusionHigh-frequency intraoral ultrasonography is a feasible, non-invasive method for real-time periodontal tissue characterization. Echogenicity provides a robust marker for tissue differentiation and inflammation detection, but further studies with larger cohorts are needed to validate its clinical utility and automate diagnostic processes.
trial registrationThe study was approved by the Institutional Ethics Committee (Approval No. 22.04642.000161) and registered on the International Clinical Trials Registry Platform (ICTRP) under the identifier NCT05809427 (07/07/2023).
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