ArticleClinical proteomics2025
Do microenvironmental changes in degenerative disc disease reflect in systemic circulation? A proteomic investigation.
Article in Clinical proteomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Gut-Intervertebral Disc Axis: Gut Microbiome-Driven Immune-Metabolic Imbalance and Intervertebral Disc Degeneration.Journal of cellular physiology · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe complement system plays a crucial role in immune regulation and inflammation, contributing to intervertebral disc degeneration (IDD) pathogenesis. While tissue-specific complement activation in degenerated discs is well-documented, its systemic expression in degenerative disc disease (DDD) plasma remains unclear.
methodsThis study employed high-throughput mass spectrometry to analyze the plasma and tissue proteomes of 40 DDD patients, comprising of Modic change (MC) and non-Modic change (NMC) patients, alongside 20 healthy volunteers (HV). Only plasma and no plasma-matched tissue samples were collected from HV group.
resultsProteomic analysis identified 707 proteins in DDD plasma and 655 in HV plasma, with 508 common. Complement and coagulation cascades were enriched, with 46 complement proteins identified. The DDD-plasma group exhibited upregulation of most complement proteins, except for C1q complex (1.38-fold) and Complement Factor D (CFD, 0.64-fold), alongside slight downregulation of vitronectin (VTN), clusterin (CLU), and complement C8G. Elevated C-reactive protein (CRP) levels were observed in DDD-plasma, indicating systemic inflammation. Correlation analysis revealed weak associations between plasma and tissue complement protein levels, suggesting potential regulatory mechanisms.
conclusionOur study reveals that systemic complement alterations in DDD, supporting their potential as blood-based biomarkers reflecting localized disc pathology. Further validation in larger cohorts across different disease stages is needed to explore their diagnostic and therapeutic implications. Data are available via ProteomeXchange with identifier PXD063403.
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