Evidence map›Paper›PMID 41372749›Full record

ArticleACS infectious diseases2026

Novel 1

Floriano Paes Silva Junior, Rafael Ferreira Dantas, Sang-Kyu Park, Helen Whiteland, Camilla Thomaz da Silva Oliveira, João M Rezende-Neto, Jordano Ferreira Reis, Josephine Forde-Thomas, Luciano Pinho Gomes, Walter C G Valente and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Floriano Paes Silva JuniorLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0003-4560-1291
Rafael Ferreira DantasLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-3914-586X
Sang-Kyu ParkDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Helen WhitelandDepartment of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K.
Camilla Thomaz da Silva OliveiraLaboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.
João M Rezende-NetoLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Jordano Ferreira ReisLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Josephine Forde-ThomasDepartment of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K.
Luciano Pinho GomesLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Walter C G ValenteLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Giuliana Viegas SchiratoLaboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Frederico Ricardo de Castro NoronhaLaboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.
Karl F HoffmannDepartment of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K.ORCID 0000-0002-3932-5502
Jonathan S MarchantDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0001-6592-0877
Sabrina Baptista FerreiraLaboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-5363-0888

Funding

Resolving the properties of schistosome TRPMPZQ, the target of the anthelmintic drug praziquantelR01AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Wei Liu, JONATHAN S MARCHANT · 2020 to 2026
$3.1M
NIAID NIH HHS R01 AI145871
6 · The paper itself

Abstract

The identification of a transient receptor potential ion channel of the melastatin subfamily activated by praziquantel (TRPM

Indexed as

AnthelminticsPraziquantelSchistosoma mansoniSchistosomicidesTriazolesTRPM Cation ChannelsAnimalsFemaleHumansLarvaMaleAnthelminticsPraziquantelSchistosomicidesTriazolesTRPM Cation Channelsphenotypic screeningpraziquantel analoguesSchistosoma mansonischistosomiasis drug discoverytriazolesTRPM modulators

Identifiers

PMID41372749
PMCPMC12718081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.