Trial reportBMC surgery2025
Positive effects of a perioperative training intervention in Ivor Lewis oesophageal surgery: a randomised, controlled multicentre trial.
Trial report in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03452319 (Effekt av ökad Fysisk träning i Samband Med Thorakoabdominell Esofaguskirurgi), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effekt av ökad Fysisk träning i Samband Med Thorakoabdominell Esofaguskirurgi
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of peri-operative training interventions in connection with oesophageal surgery have not been thoroughly investigated. The aim of this randomised, controlled, single-blind study was to evaluate a peri-operative physical training programme in patients undergoing oesophageal cancer resection surgery due to cancer of the oesophagus or the gastro-oesophageal junction.
methodsOne hundred patients scheduled to undergo Ivor Lewis oesophagectomy in one of five university hospitals in Sweden were randomised to a control group or intervention including respiratory muscle training, strength training, and increased physical activity before surgery and up to 3 months postoperatively. Outcome measures were physical capacity, respiratory muscle strength, spirometry, grip strength, and chest mobility. Questionnaires regarding physical activity and function, recovery, and health-related quality of life were completed at inclusion and 3 and 12 months postoperatively.
resultsWe did not find significant differences between the groups in physical capacity during follow-up. However, the intervention group performed significantly better than the control group in maximal inspiratory pressure (Δ18%), maximal expiratory pressure (Δ18%), and peak expiratory flow (Δ12%) 3 months postoperatively (p < 0.05). Patients in the intervention group also developed fewer pulmonary complications (p = 0.019). We did not find differences between the groups in recovery or health-related quality of life.
conclusionA peri-operative training intervention including respiratory muscle training had a positive impact on respiratory function and pulmonary complications. However, neither strength training nor increased physical activity had any effects. Thus, respiratory muscle training may be offered as a peri-operative regimen in oesophageal cancer surgery.
trial registrationFoU i VGR 238,651 (Released Dec 15, 2017), Clinical Trials NCT03452319 (Released Feb 18, 2018).
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