ReviewJournal of orthopaedic surgery and research2025
Progress in the clinical use of bone marrow aspirate concentrate for knee osteoarthritis: an expert opinion.
Review in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Beyond Cartilage Regeneration: Targeting the Subchondral Bone with Extracorporeal Shock Wave Therapy and Regenerative Medicine in Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2026Review
- Temporal Hierarchy of Hydrogels and Orthobiologic Therapies for Knee Osteoarthritis.Gels (Basel, Switzerland) · 2026Review
- Effect and comparison of bone marrow aspirate concentrate on cartilage regeneration and clinical outcomes following high tibial osteotomy and microfracture.Journal of orthopaedic surgery and research · 2026Article
- Subchondral bone marrow aspirate concentrate injection improves clinical outcomes and reduces bone marrow lesions in knee osteoarthritis: 12-month retrospective analysis.Journal of orthopaedic surgery and research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability. Orthobiological therapies aim to regenerate articular cartilage and delay or stop the progression of the degenerative lesion. Intra-articular injections of biological derivatives have been increasingly used in the last decade, although the indications for using bone marrow aspirate concentrate (BMAC) are still unclear. The present expert opinion reviewed the current literature on BMAC in the management of knee OA, providing an update on the current indications for the selection of the ideal patient, as well as the preparations and efficacy of BMAC compared to other biological alternatives. Clinical studies that investigated BMAC in the management of knee OA were identified and discussed. BMAC is a valuable source of mesenchymal stem cells, offering potential benefits in attenuating the inflammatory pathway associated with knee OA. Intra-articular administration of BMAC has shown effectiveness in clinical trials, improving the functional outcomes of patients. However, the superiority of BMAC over other orthobiologic treatments cannot be assessed, given the conflicting results presently available.
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