ArticleNature neuroscience2026
Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal-to-Ventral Axis.Hippocampus · 2026Article
- Developmental alcohol exposure: Impacts on medial prefrontal cortex morphology and the excitatory-inhibitory balance.Progress in neuro-psychopharmacology & biological psychiatry · 2026Review
- Erbin Regulates Neuronal Hyperexcitability and Seizure Susceptibility in Temporal Lobe Epilepsy.Neuroscience bulletin · 2026Article
- DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex.Pflugers Archiv : European journal of physiology · 2026Article
- Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions.Nature neuroscience · 2026Article
- High-frequency, high-intensity electrical stimulation selectively activates human fast-spiking interneurons.Frontiers in synaptic neuroscience · 2026Article
- New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach.Frontiers in computational neuroscience · 2026Review
- Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex.Journal of neurophysiology · 2025Article
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13 authors.
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Abstract
Understanding the functional principles of the human brain requires deep insight into its neuronal and network physiology. In superficial layers of temporal cortex, molecular and morphological subtypes of glutamatergic excitatory pyramidal neurons have been described, but subtyping based on electrophysiological parameters has not been performed. The extent to which pyramidal neuron subtypes contribute to the specialization of physiological interactions by forming synaptic subnetworks remains unclear. Here we performed whole-cell patch-clamp recordings of more than 1,400 layer 2-3 (L2-3) pyramidal neurons and 1,400 identified monosynaptic connections in acute slices of human temporal cortex. We extract principles of neuronal and synaptic physiology along with anatomy and functional synaptic connectivity. We also show robust classification of pyramidal neurons into four electrophysiological subtypes, corroborated by differences in morphology and decipher subtype-specific synaptic interactions. Principles of microcircuit organization are found to be conserved at the individual level. Such a fine network structure suggests that the functional diversity of pyramidal neurons translates into differential computations within the L2-3 microcircuit of the human cortex.
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