Evidence map›Paper›PMID 41372677›Full record

SynthesisClinical oral investigations2025

Association between oral diseases and oral Helicobacter pylori infection: A systematic review and meta-analysis.

Meng Wang, Pei-Hui Ding, Yun Qian, Li-Jie Fan

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Site-stratified global oralJournal of oral microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meng WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang, 310006, China.
Pei-Hui DingStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang, 310006, China.
Yun QianStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang, 310006, China.
Li-Jie FanStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang, 310006, China. ddmm55@zju.edu.cn.

Funding

the Key Research and Development Program of Zhejiang Province 2025C02099the Key Research and Development Program of Zhejiang Province 2025C02100
6 · The paper itself

Abstract

objectivesHelicobacter pylori (H. pylori) is a prevalent gastric bacterium increasingly detected in the oral cavity and may contribute to the progression of oral diseases. This study aimed to assess the association between oral diseases and oral H. pylori infection. MATERIALS AND

methodsA systematic review and meta-analysis of observational studies was conducted to compare oral H. pylori prevalence between patients with oral diseases and healthy controls. Data were pooled to estimate overall associations, and subgroup analyses were performed by oral disease type, detection site, detection methods, and region to assess their potential impact on the observed relationships.

resultsTen studies with 1166 participants met the inclusion criteria. Oral H. pylori infection was significantly associated with oral diseases (OR = 3.24, 95%CI:1.78-5.92, p = 0.0001), particularly periodontitis (OR = 4.28, 95%CI:2.46-7.44). The strongest associations were observed when H. pylori was detected in dental plaque (OR = 4.65, 95% CI: 2.60-8.33), using polymerase chain reaction (PCR)-based methods (OR = 4.09, 95% CI: 2.31-7.24), and in Asian populations. Sensitivity analyses confirmed the robustness of these results, and no publication bias was detected.

conclusionsOral H. pylori, particularly when detected in dental plaque by PCR, is strongly associated with periodontitis, suggesting that it may contribute to the progression of oral diseases. However, these findings are limited by potential confounding and the observational nature of the included studies, warranting cautious interpretation and further prospective research. CLINICAL RELEVANCE: Oral H. pylori is associated with periodontitis, highlighting the need for standardized detection methods and further prospective studies to clarify causal mechanisms and guide integrated management of oral diseases and the risk of gastric reinfection.

Indexed as

Helicobacter InfectionsHelicobacter pyloriMouth DiseasesHumansPrevalenceDental plaqueHelicobacter pyloriMeta-analysisOral healthPeriodontitis

Identifiers

PMID41372677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.