SynthesisHypertension research : official journal of the Japanese Society of Hypertension2026
Effect of morning or evening antihypertensive therapy on heart failure in community resident patients: Results of the TIME and BedMed Trials.
Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antihypertensive therapy tailored to the circadian blood pressure profile as precision medicine.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Response to Comment on: Effect of morning or evening antihypertensive therapy on heart failure in community resident patients: results of the TIME and BedMed trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Comment on "Effect of morning or evening antihypertensive therapy on heart failure in community resident patients: results of the TIME and BedMed Trials".Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the effect of morning or evening antihypertensive therapy on heart failure (HF), myocardial infarction, stroke and all-cause death in community resident patients in the TIME and BedMed trials, by study-level meta-analysis. These trials included 24,461 patients, experiencing 248 HFs, 371 myocardial infarctions, 331 strokes and 1,044 all-cause deaths. The pooled hazard ratio (HR) and 95% confidence interval (CI) between therapy groups were calculated for each event. For HF, myocardial infarction, stroke and all-cause death, the HRs (95%) CIs, P value, for evening versus morning therapy were 0.77 (0.60-0.99), P = 0.04, 1.02 (0.77-1.35), P = 0.91, 0.92 (0.74-1.14), P = 0.43, and 1.02 (0.90-1.14), P = 0.79, respectively. No heterogeneity was found for HF, stroke and all-cause death, and mild heterogeneity was observed for myocardial infarction. In the TIME and BedMed trials, compared to morning therapy, evening therapy was associated with a 23% lower risk of HF, whereas no difference was observed for other outcomes. This analysis of the TIME and BedMed trials evaluating community resident patients shows that, when compared to morning antihypertensive therapy, evening therapy was associated with a 23% lower risk of HF. CI confidence interval, HR hazard ratio.
Indexed as
Identifiers
41372676What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.