Evidence map›Paper›PMID 41372633›Full record

ArticleEMBO reports2026

JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution.

Qingxia Chen, Shuxiang Ma, Hao Liu, Juyuan Liu, Qingchao Li, Qian Lyu, Hanxiao Yin, Junkui Zhao, Shanshan Nai, Ting Song and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qingxia Chen *Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Institute of Early Life Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China.
Shuxiang Ma *Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China.ORCID 0009-0007-0021-4235
Hao Liu *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Juyuan LiuKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Qingchao LiCenter for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China.ORCID 0000-0002-0307-0085
Qian LyuCenter for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China.
Hanxiao YinState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, 300071, Tianjin, China.ORCID 0000-0002-6764-8632
Junkui ZhaoState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, 300071, Tianjin, China.
Shanshan NaiCenter for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China.
Ting SongCenter for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China.
Hongbin LiuCheeloo College of Medicine, Shandong University, 250012, Jinan, China.ORCID 0000-0003-2550-7492
Jun ZhouCenter for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China.ORCID 0000-0003-3131-7804
Xiumin YanMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Institute of Early Life Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China.ORCID 0000-0002-3260-1690
Xueliang ZhuKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China. xlzhu@sibcb.ac.cn.ORCID 0000-0001-8019-9336
Huijie ZhaoCenter for Cell Structure and Function, College of Life Sciences, Shandong Normal University, 250014, Jinan, China. huijiezhao@sdnu.edu.cn.ORCID 0000-0002-8595-8159

Funding

MOST | National Natural Science Foundation of China (NSFC) 32230027MOST | National Natural Science Foundation of China (NSFC) 32270807MOST | National Natural Science Foundation of China (NSFC) 32500663| Natural Science Foundation of Shandong Province () ZR2024QC038Taishan Scholar Foundation of Shandong Province () tsqn202211109
6 · The paper itself

Abstract

Motile cilia are evolutionarily conserved protrusions critical for motility and homeostasis. Their rhythmic movements require the central pair microtubules (CP-MTs). While the initial CP-MT assembly in mammals is mediated by WDR47 and microtubule minus-end-binding CAMSAPs, the mechanism by which CP-MTs are stabilized remains unclear. Here, we demonstrate that WDR47 coordinates JHY and SPEF1 to maintain the stability of mammalian CP-MTs. By generating a proximity interactome of WDR47, we identify a group of CP-MT-associated proteins, including SPEF1 and JHY. WDR47 enriches JHY and SPEF1 to the central lumen and tip of nascent cilia, whereas SPEF1 recruits WDR47 and JHY to CP-MTs through direct interactions. Jhy deficiency in mice preferentially disrupts distal CP-MTs, resulting in rotatory ciliary beats. Phylogenetic analyses suggest conserved functions of WDR47 and SPEF1 in protozoa and metazoans, as well as a role for JHY in animals with radial or bilateral body symmetry. We propose that JHY emerges to further reinforce CP-MTs, enabling the transition from switchable to fixed ciliary waveforms in metazoan evolution.

Indexed as

Biological EvolutionCiliaMicrotubule-Associated ProteinsAnimalsEvolution, MolecularHumansMiceMicrotubulesPhylogenyMicrotubule-Associated ProteinsCentral Pair MicrotubuleCiliary MotilityCiliopathyMotile CiliaPrimary Ciliary Dyskinesia

Identifiers

PMID41372633
PMCPMC12979858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.