Evidence map›Paper›PMID 41372559›Full record

ArticleCerebellum (London, England)2025

Effect of Aminopyridines on Oculomotor Dysfunction in Anti-GAD Ataxia: A Brief Report.

Pavol Skacik, Milan Grofik, Egon Kurca, Stefan Sivak

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pavol SkacikNeurology Department Jessenius Faculty of Medicine and University Hospital Martin, Kollarova 2, 036 01, Martin, Slovakia. skacik1@uniba.sk.ORCID http://orcid.org/0000-0001-5630-9822
Milan GrofikNeurology Department Jessenius Faculty of Medicine and University Hospital Martin, Kollarova 2, 036 01, Martin, Slovakia.ORCID http://orcid.org/0000-0003-0464-0497
Egon KurcaNeurology Department Jessenius Faculty of Medicine and University Hospital Martin, Kollarova 2, 036 01, Martin, Slovakia.ORCID http://orcid.org/0000-0002-1025-6830
Stefan SivakNeurology Department Jessenius Faculty of Medicine and University Hospital Martin, Kollarova 2, 036 01, Martin, Slovakia.ORCID http://orcid.org/0000-0002-0348-3082

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aminopyridines (APs) enhance Purkinje cell excitability and are effective for several cerebellar and ocular motor syndromes, including downbeat nystagmus. Their use in anti-glutamic acid decarboxylase (GAD) cerebellar ataxia has not previously been described. A 69-year-old woman with confirmed anti-GAD cerebellar ataxia underwent clinical and videonystagmography (VNG) assessments at baseline, Day 7, and Day 30 after start of fampridine 20 mg/day. Baseline VNG showed pronounced downbeat nystagmus and frequent square-wave jerks. By Day 7, downbeat nystagmus had fully resolved with a marked reduction in square-wave jerks, accompanied by improvement in oscillopsia and diplopia. Findings remained stable at Day 30. SARA scores remained unchanged, with persistent gait, stance, and other cerebellar motor deficits. Fampridine was associated with rapid and sustained improvement in oculomotor dysfunction in this patient with anti-GAD cerebellar ataxia. APs may offer adjunctive symptomatic benefit in selected individuals with visually disabling downbeat nystagmus. Controlled studies are needed to confirm these observations.

Indexed as

AminopyridinesCerebellar AtaxiaGlutamate DecarboxylaseOcular Motility DisordersAgedFemaleHumansNystagmus, PathologicAminopyridinesGlutamate DecarboxylaseAminopyridinesAnti-GAD cerebellar ataxiaDownbeat nystagmusVideonystagmography

Identifiers

PMID41372559
PMCPMC12696138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.