ArticleBritish journal of cancer2026
RNLS hypomethylation as a potential epigenetic marker of lung cancer metastasis: an epigenome-wide association study.
Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Noninvasive Circulating Tumor DNA Methylation Classifier to Identify Benign Pulmonary Nodules.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
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7 authors.
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Abstract
backgroundLung cancer is highly lethal because most patients have already developed metastases at diagnosis, yet the epigenetic mechanisms driving metastasis are unclear.
methodsWe performed an epigenome-wide association study on 42 lung cancer patients to identify differentially methylated positions (DMPs) in pulmonary tumour (PT), paratumor (PP), and normal (PN) tissues, and in peripheral blood. The impact of DMPs on gene expression and associated signalling pathways was examined. Functional validation included gene silencing in A549 and H1299 cells, analysis of the affected signalling pathway, and assessment of metastasis using mice injected with genetically edited cells.
resultsWe identified 22 significant DMPs between PP and PN tissues, with several mapped to the RNLS promoter region, showing progressive hypomethylation from PN, PP, to PT. This hypomethylation was also present in the peripheral blood of patients who later developed metastasis. RNLS methylation was inversely correlated with its expression across multiple tissue types. The DMPs were enriched in Notch signalling. Silencing RNLS inhibited cancer cell proliferation and migration, and downregulated Notch signalling. RNLS deficiency reduced metastatic burden in mice.
conclusionsRNLS hypomethylation is an epigenetic alteration associated with lung cancer metastasis, with potential as an early biomarker and as a therapeutic target.
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