ArticleNature2026
Mapping the genetic landscape across 14 psychiatric disorders.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Pooled it
- Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations.Nature human behaviour · 2026Pooled it
- Inflammatory cytokine alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and network meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Inflammatory cytokine alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and network meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- A multi-cohort assessment of the polygenic prediction in ADHD treatment response.Psychiatry research · 2026Pooled it
- Epigenetics of bipolar disorder: a bibliometric landscape and visualization analysis.Frontiers in psychiatry · 2026Pooled it
- The neurodevelopmental spectrum: phenotypic architecture, etiology, predictive utility, and specificity across development.Molecular psychiatry · 2026Article
- Beyond Depression and Chronic Pain: Toward Understanding the Complex Developmental Pathways to Self-Harm.Biological psychiatry global open science · 2026Article
- Multi-omic spatial mapping of the human habenula defines the molecular and anatomical organization of medial and lateral subregions.bioRxiv : the preprint server for biology · 2026Article
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Neuropsychiatry genetics in Africa.Nature communications · 2026Review
- Vitamin A deficiency induces sex-specific reward processing alterations through a dysregulation of the mesolimbic dopamine transmission in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Attention-deficit/hyperactivity disorder polygenic risk score and incidence of cognitive impairment in older adults: A prospective multicohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Multivariate genetic analyses test for the presence of a general 'JCPP advances · 2026Article
- A founder population reveals genetic variation with major effect on serious mental illness.medRxiv : the preprint server for health sciences · 2026Article
- Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper.NPP - digital psychiatry and neuroscience · 2026Article
- The genetic overlap between schizophrenia and major depression with cognitive function.Molecular psychiatry · 2026Article
- Common genetic variants are associated with increased likelihood of latent co-occurring neurodevelopmental and mental health factors among autistic individuals.Molecular psychiatry · 2026Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors.
Andrew D Grotzinger *Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. andrew.grotzinger@colorado.edu.ORCID 0000-0001-7852-9244
Josefin Werme *Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Wouter J Peyrot *Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Oleksandr Frei *Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.ORCID 0000-0002-6427-2625
Christiaan de LeeuwDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1076-9828
Lucy K BicksDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Qiuyu GuoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Michael P MargolisDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Anthony BatzlerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Vanessa PazdernikDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9350-4440
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-4461-3568
Verneri AnttilaAnalytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Anders D BørglumCenter for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Gerome BreenSocial Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID 0000-0003-2053-1792
Na CaiComputational Health Centre, Helmholtz Munich, Neuherberg, Germany.
Ditte DemontisCenter for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.ORCID 0000-0001-9124-2766
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-0344-9690
Stephen V FaraoneDepartment of Neuroscience and Physiology, Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Barbara FrankeDepartment of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4375-6572
Michael J GandalDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5800-5128
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4067-1859
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-8002-7267
John M HettemaDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-0394-777X
Katherine G JonasDepartment of Psychiatry & Behavioral Health, Stony Brook University, New York, NY, USA.ORCID 0000-0002-1910-223X
James A KnowlesDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Karestan C KoenenBroad Institute of MIT and Harvard, Boston, MA, USA.
Adam X MaihoferCenter of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Travis T MallardCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3265-3001
Manuel MattheisenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-8442-493X
Karen S MitchellDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Benjamin M NealeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1513-6077
Caroline M NievergeltCenter of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
John I NurnbergerDepartment of Medical and Molecular Genetics, Department of Psychiatry, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Kevin S O'ConnellNORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Roseann E PetersonDepartment of Psychiatry and Behavioral Sciences, Institute for Genomics in Health, SUNY Downstate Health Sciences University, New York, NY, USA.ORCID 0000-0001-6402-849X
Elise B RobinsonStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2314-2792
Sandra S Sanchez-RoigeDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Susan L SantangeloCenter for Clinical and Translational Science, Maine Health Institute for Research, Portland, ME, USA.ORCID 0000-0001-5576-4495
Jeremiah M ScharfPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hreinn StefanssonAmgen-deCODE Genetics, Reykjavik, Iceland.ORCID 0000-0002-9331-6666
Kari StefanssonAmgen-deCODE Genetics, Reykjavik, Iceland.
Murray B SteinDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9564-2871
Nora I StromCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.ORCID 0000-0002-5261-8852
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Elliot M Tucker-DrobCenter on Aging and Population Sciences, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-5599-6237
Brad VerhulstDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA.
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6862-1837
G Bragi WaltersAmgen-deCODE Genetics, Reykjavik, Iceland.ORCID 0000-0002-5415-6487
Naomi R WrayDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0001-7421-3357
Dongmei YuPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Anxiety Disorders Working Group of the Psychiatric Genomics Consortium
Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium
Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Eating Disorders Working Group of the Psychiatric Genomics Consortium
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Nicotine Dependence GenOmics (iNDiGO) Consortium
Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium
Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Substance Use Disorders Working Group of the Psychiatric Genomics Consortium
Phil H LeePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1770-3100
Kenneth S KendlerVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0001-8689-6570
Jordan W SmollerBroad Institute of MIT and Harvard, Boston, MA, USA. jsmoller@mgb.org.ORCID 0000-0002-0381-6334
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MUnderstanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Frances E. Carr · 2017 to 2026
$51.6MVALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI LAUREN M McGRATH · 1990 to 2026
$44.9MProject 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JENNIFER T WOLSTENHOLME · 2014 to 2026
$19.6MAfrican Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7MSleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9MPsychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4MSLE Treatment with N-acetylcysteineU01AR076092 · NIAMS · UPSTATE MEDICAL UNIVERSITY · PI Michael P McDermott, Andras Perl · 2020 to 2026
$7.9MIntegrating Common and Rare Variation to Discover Genes Associated with Tourette SyndromeR01NS102371 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATHEWS, CAROL A, OPHOFF, ROEL A · 2018 to 2022
$7.4M4/4-Psychiatric GWAS Consortium:Genomic Follow-Up Next-Gen Sequencing & GenotypiU01MH096296 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SKLAR, PAMELA · 2012 to 2015
$7.3MLatino Ancestry Genomic Psychiatry CohortR01MH123451 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2020 to 2025
$7.1MPerson-centered diagnostics and prediction for child dysregulatory psychopathology using novel phenotypesU01MH135970 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARALUNAS, SARAH LYN, NAGEL, BONNIE J. · 2024 to 2025
$6.5MBLRD VA IK2 BX006536NIAAA NIH HHS K01 AA030083NIAAA NIH HHS K24 AA030788NIAAA NIH HHS P50 AA022537NIAMS NIH HHS U01 AR076092NIA NIH HHS P30 AG066614NIA NIH HHS R01 AG073593NICHD NIH HHS P2C HD042849NICHD NIH HHS P50 HD027802NICHD NIH HHS P50 HD103538NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS R01 DA054869NIGMS NIH HHS R01 GM148494NIGMS NIH HHS U54 GM115516NIMH NIH HHS F30 MH135712NIMH NIH HHS K08 MH122673NIMH NIH HHS K08 MH135343NIMH NIH HHS R01 MH093500NIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH112904NIMH NIH HHS R01 MH116037NIMH NIH HHS R01 MH119243NIMH NIH HHS R01 MH120219NIMH NIH HHS R01 MH121521NIMH NIH HHS R01 MH121924NIMH NIH HHS R01 MH123451NIMH NIH HHS R01 MH123775NIMH NIH HHS R01 MH123922NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124847NIMH NIH HHS R01 MH124851NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH124873NIMH NIH HHS R01 MH124875NIMH NIH HHS R01 MH125938NIMH NIH HHS R01 MH130899NIMH NIH HHS R01 MH131685NIMH NIH HHS R01 MH136149NIMH NIH HHS R01 MH137208NIMH NIH HHS R01 MH137213NIMH NIH HHS R01 MH137218NIMH NIH HHS R01 MH137220NIMH NIH HHS R21 MH123908NIMH NIH HHS U01 MH085508NIMH NIH HHS U01 MH085513NIMH NIH HHS U01 MH085518NIMH NIH HHS U01 MH085520NIMH NIH HHS U01 MH094411NIMH NIH HHS U01 MH094421NIMH NIH HHS U01 MH094432NIMH NIH HHS U01 MH096296NIMH NIH HHS U01 MH109499NIMH NIH HHS U01 MH109501NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109528NIMH NIH HHS U01 MH109532NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539NIMH NIH HHS U01 MH125050NIMH NIH HHS U01 MH135970NIMH NIH HHS U24 MH068457NINDS NIH HHS R01 NS102371NINDS NIH HHS R01 NS105746NINDS NIH HHS R01 NS128535
Abstract
Psychiatric disorders display high levels of comorbidity and genetic overlap
Indexed as
Mental DisordersAdultBipolar DisorderChildFemaleGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansMajor Depressive DisorderMaleMultifactorial InheritanceSchizophreniaStress Disorders, Post-Traumatic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.