Evidence map›Paper›PMID 41372412›Full record

ArticleNature2026

A direct role for a mitochondrial targeting sequence in signalling stress.

Zixuan Yuan, Megan Balzarini, Marina Volpe, Madeleine Goldstein, Tony Shengzhe Peng, Elizabeth Hui, Nancy Neng Fang, Waleed S Albihlal, Melika Hajimohammadi, Kevin Wei and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Regulation of cellular proteostasis via mitochondrial protein import.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  2. Article
  3. The role of the nucleus in the control of mitochondrial precursor proteins in yeast.Protein science : a publication of the Protein Society · 2026
    Review
  4. Quality control of protein import into mammalian mitochondria.Protein science : a publication of the Protein Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zixuan YuanLife Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Megan BalzariniLife Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0009-0006-6404-010X
Marina VolpeLife Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Madeleine GoldsteinLife Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-8193-1194
Tony Shengzhe PengLife Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0009-0000-2482-9786
Elizabeth HuiDepartment of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Nancy Neng FangDepartment of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Waleed S AlbihlalCell Fate and Gene Regulation Laboratory, The Francis Crick Institute, London, UK.
Melika HajimohammadiLife Sciences Institute, Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
Kevin WeiLife Sciences Institute, Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
Calvin K YipLife Sciences Institute, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-1779-9501
Folkert J van WervenCell Fate and Gene Regulation Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0002-6685-2084
Thibault MayorDepartment of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-9289-3939
Hilla WeidbergLife Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada. hilla.weidberg@ubc.ca.

Funding

Medical Research Council CC2043Wellcome Trust CC2043
6 · The paper itself

Abstract

Mitochondrial protein import is required for maintaining organellar function

Indexed as

MitochondriaMitochondrial ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionStress, PhysiologicalCell NucleusDNA-Binding ProteinsGene Expression Regulation, FungalHSP70 Heat-Shock ProteinsProtein TransportTranscription FactorsTranscription, GeneticDNA-Binding ProteinsHSP70 Heat-Shock ProteinsMitochondrial ProteinsSaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID41372412
PMCPMC7618714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.