Evidence map›Paper›PMID 41372409›Full record

ArticleNature2026

Human gut M cells resemble dendritic cells and present gluten antigen.

Daisong Wang, Sangho Lim, Willine J van de Wetering, Carmen Lopez-Iglesias, Yuu Okura, Yuri Teranishi-Ikawa, Akihiko Mizoroki, Willem Kasper Spoelstra, Talya Dayton, Gijs J F van Son and 10 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026
    Article
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  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Daisong Wang *Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, UMC Utrecht, Utrecht, The Netherlands.ORCID 0009-0005-9194-8132
Sangho Lim *Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, UMC Utrecht, Utrecht, The Netherlands.
Willine J van de WeteringThe Microscopy CORE Lab, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-0311-978X
Carmen Lopez-IglesiasThe Microscopy CORE Lab, Maastricht University, Maastricht, The Netherlands.
Yuu OkuraChugai Pharmaceutical, Tokyo, Japan.ORCID 0000-0002-6949-8105
Yuri Teranishi-IkawaChugai Pharmaceutical, Tokyo, Japan.
Akihiko MizorokiChugai Pharmaceutical, Tokyo, Japan.
Willem Kasper SpoelstraAMOLF Institute, Amsterdam, The Netherlands.ORCID 0000-0002-7940-0829
Talya DaytonHubrecht Institute, Royal Netherlands Academy of Arts and Sciences, UMC Utrecht, Utrecht, The Netherlands.
Gijs J F van SonThe Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0003-0572-3243
Apollo PronkDepartment of Surgery, Diakonessenhuis Utrecht and Zeist, Utrecht, The Netherlands.
Niels SmakmanDepartment of Surgery, Diakonessenhuis Utrecht and Zeist, Utrecht, The Netherlands.
Gieneke B C Gonera-de JongDepartment of Pediatrics, Wilhelmina Hospital Assen, Assen, The Netherlands.
Sebo WithoffDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iris H JonkersDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-2304-7939
Jeroen S van ZonAMOLF Institute, Amsterdam, The Netherlands.ORCID 0000-0002-6021-2924
Sander J TansAMOLF Institute, Amsterdam, The Netherlands.ORCID 0000-0002-7131-2568
Peter J PetersThe Microscopy CORE Lab, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-2964-5684
Johan H van EsHubrecht Institute, Royal Netherlands Academy of Arts and Sciences, UMC Utrecht, Utrecht, The Netherlands.
Hans CleversHubrecht Institute, Royal Netherlands Academy of Arts and Sciences, UMC Utrecht, Utrecht, The Netherlands. h.clevers@hubrecht.eu.ORCID 0000-0002-3077-5582

Funding

Netherlands Organ-on-Chip Initiative, an NWO Gravitation project
6 · The paper itself

Abstract

Microfold (M) cells are rare intestinal epithelial cells that reside in the follicle-associated epithelium of Peyer's patches

Indexed as

Antigen PresentationGlutensM CellsAnimalsCeliac DiseaseCell DifferentiationCoculture TechniquesDendritic CellsEnterocytesGene Expression ProfilingHistocompatibility Antigens Class IIHLA-DQ AntigensHumansMiceOrganoidsPeyer's PatchesGlutensHistocompatibility Antigens Class IIHLA-DQ2 antigenHLA-DQ Antigens

Identifiers

PMID41372409
PMCPMC12872457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.