Evidence map›Paper›PMID 41372408›Full record

ArticleNature2026

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity.

Xiaoying Tian, Jiaqi Liu, Yuxi Li, Yupeng Wang, Yuanhanyu Luo, Huabin He, Yang She, Yan Ma, Jingjin Ding, Ping Zhou and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. ALPK1 agonists: a new strategy for cancer immunotherapy.Signal transduction and targeted therapy · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoying Tian *Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China.ORCID 0000-0003-1698-6065
Jiaqi Liu *Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China.ORCID 0009-0005-2287-5400
Yuxi LiNational Institute of Biological Sciences, Beijing, P. R. China.
Yupeng WangNational Institute of Biological Sciences, Beijing, P. R. China.
Yuanhanyu LuoNational Institute of Biological Sciences, Beijing, P. R. China.ORCID 0009-0007-4787-4644
Huabin HeNational Institute of Biological Sciences, Beijing, P. R. China.
Yang SheNational Institute of Biological Sciences, Beijing, P. R. China.
Yan MaNational Institute of Biological Sciences, Beijing, P. R. China.
Jingjin DingNational Institute of Biological Sciences, Beijing, P. R. China.ORCID 0000-0001-9941-7997
Ping ZhouNational Institute of Biological Sciences, Beijing, P. R. China.ORCID 0000-0002-8517-6480
Chao LiNational Institute of Biological Sciences, Beijing, P. R. China.ORCID 0000-0003-4529-5570
Feng ShaoNational Institute of Biological Sciences, Beijing, P. R. China. shaofeng@nibs.ac.cn.ORCID 0000-0002-9562-7791

Funding

Basic Science Center ProjectNational Natural Science Foundation of ChinaStrategic Priority Research Program of Chinese Academy of Sciences
6 · The paper itself

Abstract

Targeting innate immunity holds promise in cancer immunotherapy, particularly in improving checkpoint inhibitors. However, the use of agonists of the promising innate receptors TLRs and STING

Indexed as

NeoplasmsProtein KinasesAnimalsCD8-Positive T-LymphocytesChemokine CCL2Chemokine CXCL10ColitisCytosolDendritic CellsFemaleHumansImmune Checkpoint InhibitorsImmunity, InnateImmunotherapyMacrophagesMaleALPK1 protein, mouseChemokine CCL2Chemokine CXCL10Immune Checkpoint InhibitorsMembrane ProteinsProtein Kinases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.