ArticleNature2026
Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- Review
- LINE-1 Deregulation in Ovarian Cancer: Implications for Diagnosis, Prognosis, and Therapeutic Targeting.Molecular diagnosis & therapy · 2026Review
- LINE-1 Epigenetic Repression and Regulation of Immunity.Viruses · 2026Review
- Mutations in Exon 29 of Ring Finger Protein 213 Are Associated with Early-Onset Colorectal Cancer.Digestive diseases and sciences · 2026Article
- LINE-1 retrotransposons: Multifaceted functions and regulatory mechanisms in health and disease.Molecular therapy. Nucleic acids · 2026Review
- Review
- Article
- Article
- A lunapark for secretory mRNA translation at ER junctions.Nature reviews. Molecular cell biology · 2026Article
- Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma.bioRxiv : the preprint server for biology · 2025Article
- The early-onset cancer epidemics: evidence synthesis using the prospective cohort incident-tumor biobank method.European journal of epidemiology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
68 authors.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2124-2706
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5103-3871
Christopher WirthManchester Cancer Research Centre, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-1800-0899
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0658-0467
Jinhu YinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0009-0000-3153-4126
Monia CecatiAdvanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy.
Francesca MarchegianiClinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9265-8525
Charles LeducDepartment of Pathology, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Marina K BaineDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William D TravisDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9532-9735
Philippe JoubertInstitut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Michelle AntonyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alyssa KleinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Azhar KhandekarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Caleb HartmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jennifer RosenbaumWestat, Rockville, MD, USA.
Frank J Colón-MatosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mona MiraftabDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Monjoy SahaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6470-3544
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5389-6267
Kristine M JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1584-8920
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Maria Pik WongQueen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Kin Chung LeungDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Eric S EdellDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Jacobo Martínez SantamaríaBiobanco IBSP-CV FISABIO, Valencia, Spain.ORCID http://orcid.org/0009-0000-4351-3955
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-3241-3216
Sai S YendamuriThoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Marta ManczukDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warshaw, Poland.ORCID http://orcid.org/0000-0002-4319-6424
Jolanta LissowskaDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warshaw, Poland.ORCID http://orcid.org/0000-0003-2695-5799
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.ORCID http://orcid.org/0000-0003-3757-3868
Anush MukeriaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Oxana ShanginaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Ivana HolcatovaInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Dana MatesDepartment of Occupational Health and Toxicology, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania.
Sasa MilosavljevicInternational Organisation for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Milan SavicDepartment of Thoracic Surgery, Clinical Center of Serbia, Belgrade, Serbia.
Yohan BosséInstitut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.ORCID http://orcid.org/0000-0002-3067-3711
Bonnie E Gould RothbergSylvester Comprehensive Cancer Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-8919-4467
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0301-0242
Valerie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Geoffrey LiuPrincess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
Paul HofmanIHU RespirERA, Biobank-BB-0033-0025, Côte d'Azur University, Nice, France.ORCID http://orcid.org/0000-0003-0431-9353
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2055-5885
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-0261-3252
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-8935-3843
Lixing YangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0172-5516
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8606-4707
Kevin BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3596-4515
Jiyeon ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0955-2384
Maurizio CardelliAdvanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy.ORCID http://orcid.org/0000-0002-4480-2473
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0888-8839
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, MA, USA.
David C WedgeManchester Cancer Research Centre, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7572-3196
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. landim@mail.nih.gov.ORCID http://orcid.org/0000-0003-4507-329X
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MStudies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MIntramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP101231NCI NIH HHS N02 CP001006NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA269919NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547World Health Organization 001
Abstract
Understanding lung cancer evolution can identify tools for intercepting its growth
Indexed as
Adenocarcinoma of LungClonal EvolutionLong Interspersed Nucleotide ElementsLung NeoplasmsDNA Copy Number VariationsDNA MethylationErbB ReceptorsFemaleGenomic InstabilityHumansMaleMiddle AgedMutationPromoter Regions, GeneticProto-Oncogene Proteins p21(ras)SmokingEGFR protein, humanErbB ReceptorsKRAS protein, humanProto-Oncogene Proteins p21(ras)
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.