Evidence map›Paper›PMID 41372375›Full record

ArticleScientific reports2025

Structural and biological characterization of carbon-graphene biomaterials derived from black liquor with functional properties for bone tissue engineering.

Patricia de Almeida-Mattos, Gustavo Lara Achôa, Danyela Cardoso Carvalho, Taro Inagaki, Marilia Lucas Siena Del-Bel, Daniel Navarro da Rocha, José Ricardo Muniz Ferreira, Mariah Cationi Hirata, Gisele Aparecida Amaral-Labat, Rodrigo Labat Marcos and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Patricia de Almeida-MattosDepartamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, São Paulo, Brasil.
Gustavo Lara AchôaInstituto Sírio-Libanês de Ensino e Pesquisa, São Paulo, Brasil.
Danyela Cardoso CarvalhoDepartamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, São Paulo, Brasil.
Taro InagakiRegenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine, University of California in Los Angeles (UCLA), Los Angeles, USA.
Marilia Lucas Siena Del-BelDepartamento de Biofotônica Aplicada às Ciências da Saúde, Universidade Nove de Julho (UNINOVE), São Paulo, Brasil.
Daniel Navarro da RochaInstituto Militar de Engenharia Mecânica - IME, Rio de Janeiro, Brasil.
José Ricardo Muniz FerreiraInstituto Militar de Engenharia Mecânica - IME, Rio de Janeiro, Brasil.
Mariah Cationi HirataDepartamento de Bioengenharia, R-Crio Criogenia S.A, São Paulo, Brasil.
Gisele Aparecida Amaral-LabatInstituto Nacional de Pesquisas Espaciais, INPE, São Paulo, Brasil.
Rodrigo Labat MarcosDepartamento de Biofotônica Aplicada às Ciências da Saúde, Universidade Nove de Julho (UNINOVE), São Paulo, Brasil.
Reza JarrahyRegenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine, University of California in Los Angeles (UCLA), Los Angeles, USA.
Akishige HokugoRegenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine, University of California in Los Angeles (UCLA), Los Angeles, USA.
Daniela Franco BuenoDepartamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, São Paulo, Brasil. dbuenousp@gmail.com.
Guilherme Frederico Bernardo Lenz E SilvaDepartamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, São Paulo, Brasil. guilhermelenz@usp.br.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88882.333401/2019-01Fundação de Amparo à Pesquisa do Estado de São Paulo 18/18890-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/12954National Post-doctoral Program of the Coordination of Superior Level Staff Improvement, PNPD-CAPES 88882.315554/2019-01Technological Development and Innovative Extension (DT) category 2 of the Brazilian National Council for Scientific and Technological Development 303054/2023-9
6 · The paper itself

Abstract

Carbon-based biomaterials are promising for the field of tissue bioengineering due to their biocompatibility, high porosity, and physicochemical properties that allow functionalization and combination with other materials. In this study, carbon derived from black liquor was used to develop bone grafts. This carbon matrix (CA) was associated with nanomaterials-graphene, graphene oxide, and nano-graphite (CAG, CAGO, and CANG, respectively)-for potential applications in the repair of orofacial malformations. The scaffolds were evaluated for biocompatibility and their effect on cell viability using mesenchymal stem cells, followed by implantation in 16 male Wistar rats with non-critical bone defects in both tibias. Histological analysis demonstrated that all scaffolds were biocompatible, with defects showing repair, osteoprogenitor cell presence, and vascular channel formation. Histomorphometric assessment of bone neoformation revealed the highest repair potential in the CAG group (89% at 30 days), while the other groups showed similar bone formation: CA = 72%, CAGO = 69%, and CANG = 80%. All scaffolds promoted bone tissue formation, with the carbon-graphene scaffold yielding the greatest percentage of new bone.

Indexed as

Biocompatible MaterialsBone and BonesCarbonGraphiteTissue EngineeringAnimalsBone RegenerationCell SurvivalMaleMesenchymal Stem CellsOsteogenesisRatsRats, WistarTissue ScaffoldsBiocompatible MaterialsCarbongraphene oxideGraphiteBone repairCarbon-graphene scaffoldCarbon related biomaterialsTissue engineering

Identifiers

PMID41372375
PMCPMC12770465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.