Evidence map›Paper›PMID 41372367›Full record

ArticleScientific reports2025

Periplaneta americana glycoprotein alleviates fatigue through modulation of oxidative stress and gut microbiota.

Zhongze Chen, Xiao Yang, Jingyu Zhang, Kailing Li, Rongmao He, Yongshou Yang, Jingxuan Wan, Zhengchun He, Peiyun Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongze Chen *Engineering Research center for Development of the Periplaneta americana industry of Yunnan Provincial Department of Education, Dali University, Dali, 671000, China.
Xiao Yang *Department of Breast Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Jingyu ZhangEngineering Research center for Development of the Periplaneta americana industry of Yunnan Provincial Department of Education, Dali University, Dali, 671000, China.
Kailing LiCollege of Pharmacy, Dali University, Dali, 671000, China.
Rongmao HeCollege of Pharmacy, Dali University, Dali, 671000, China.
Yongshou YangCollege of Pharmacy, Dali University, Dali, 671000, China.
Jingxuan WanEngineering Research center for Development of the Periplaneta americana industry of Yunnan Provincial Department of Education, Dali University, Dali, 671000, China.
Zhengchun HeCollege of Pharmacy, Dali University, Dali, 671000, China. hezc@dali.edu.cn.
Peiyun XiaoEngineering Research center for Development of the Periplaneta americana industry of Yunnan Provincial Department of Education, Dali University, Dali, 671000, China. xiaopeiyun@dali.edu.cn.

Funding

Yunnan Provincial Science and Technology Department 202401BA070001-007Yunnan Provincial Science and Technology Department 202405AF140044
6 · The paper itself

Abstract

Fatigue is an increasingly prominent global health issue. Periplaneta americana glycoprotein (PAG) possesses multiple pharmacological activities including antioxidation, regulation of gut microbiota (GM) and immunity, which are highly consistent with the targets of anti-fatigue treatment. This study aimed to investigate the efficacy and mechanisms of PAG in anti-fatigue. Initially, the antioxidant activity of PAG was evaluated in vitro. Subsequently, a fatigue mouse model was established to evaluate its anti-fatigue effects in vivo. Finally, Spearman correlation analysis was conducted to explore correlations between gut microbiota shifts, short-chain fatty acid (SCFA) production, and fatigue indicators. The results showed that PAG possesses significant antioxidant activity. Furthermore, PAG alleviated fatigue through multiple pathways: it prolonged swimming time, ameliorated liver injury, increased the activities of liver glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), reduced liver malondialdehyde (MDA) levels, decreased serum blood urea nitrogen (BUN) and muscle lactic acid (LA) accumulation, inhibited serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities, promoted glycogen storage in the liver and muscles of fatigued mice, altered the composition and structure of GM, and increased SCFA levels. In conclusion, these findings demonstrate that PAG alleviates fatigue by improving oxidative stress, regulating energy metabolism, and modulating the GM-SCFA axis.

Indexed as

FatigueGastrointestinal MicrobiomeGlycoproteinsOxidative StressPeriplanetaAnimalsAntioxidantsDisease Models, AnimalFatty Acids, VolatileLiverMaleMiceAntioxidantsFatty Acids, VolatileGlycoproteinsAnti-fatigueAntioxidantGut microbiotaPeriplaneta americana glycoprotein

Identifiers

PMID41372367
PMCPMC12804747

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.