Evidence map›Paper›PMID 41372315›Full record

ArticleScientific reports2025

Reactive oxygen species-sensitive release of cephalexin from hyaluronic acid-g-cephalexin dimer copolymer for treatment of inflammation and infection of oral soft tissue cells.

Chang-Young Kim, Woong Kim, Min-Suk Kook, Ji-Sun Park, Se-Yoon Park, Ho-Joong Kim, Young-Il Jeong, Seok-Jun Kim

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chang-Young Kim *Department of Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Woong Kim *Institute of Well-Aging Medicare and Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.
Min-Suk KookDepartment of Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Ji-Sun ParkInterdisciplinary Program of Perfume and Cosmetic, Chonnam National University, Gwangju, 61186, Republic of Korea.
Se-Yoon ParkDepartment of Chemistry, Chosun University, Gwangju, 61452, Korea.
Ho-Joong KimDepartment of Chemistry, Chosun University, Gwangju, 61452, Korea.
Young-Il JeongInstitute of Well-Aging Medicare and Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea. jeongyi@chosun.ac.kr.
Seok-Jun KimInstitute of Well-Aging Medicare and Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea. heaven1472@chosun.ac.kr.

Funding

Global-Learning & Academic Research Institution for Master's·PhD students and Postdocs (LAMP) Program of the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education RS-2023-00285353National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) NRF-2023R1A2C1007554National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) RS-2023-00244707
6 · The paper itself

Abstract

Since inflammation and/or infection against soft tissue cells increased oxidative stress and CD44 receptor expression, graft copolymer was synthesized using hyaluronic acid (HA) and cephalexin (CPX). To produce CPX dimer, to molecules of CPX were conjugated with carboxylic acid group of thioketal dicarboxylic acid (ThdCOOH). CPX dimer was conjugated with HA using thioketal diamine (ThdNH

Indexed as

CephalexinHyaluronic AcidInflammationReactive Oxygen SpeciesAnti-Bacterial AgentsCell LineDrug LiberationHumansHyaluronan ReceptorsNanoparticlesPolymersWound HealingAnti-Bacterial AgentsCephalexinHyaluronan ReceptorsHyaluronic AcidPolymersReactive Oxygen SpeciesCD44CephalexinHyaluronic acidInfectionInflammationOral soft tissueOxidative stress

Identifiers

PMID41372315
PMCPMC12789125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.