Evidence map›Paper›PMID 41372250›Full record

ArticleScientific reports2025

Bioactive compounds from Sargassum horneri attenuates inflammation and obesity regulating by Nrf2/HO-1 and AMPK signaling pathways.

Ramakrishna Chilakala, Hyeon Jeong Moon, Min Ju Kim, Kang Ho Ko, Jong Won Han, Min Seouk Jung, Sun Hee Cheong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anti-Obesity Effects ofInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ramakrishna ChilakalaDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea.
Hyeon Jeong MoonDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea.
Min Ju KimDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea.
Kang Ho KoDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea.
Jong Won HanDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea.
Min Seouk JungDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea.
Sun Hee CheongDepartment of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea. sunny3843@jnu.ac.kr.ORCID 0000-0001-9120-1892

Funding

National Research Foundation of Korea RS-2023-00217471
6 · The paper itself

Abstract

Sargassum horneri is rich in bioactive compounds, including phytosterols, exhibits antioxidant, anti-obesity and anti-inflammation properties; however, its underlying mechanisms remain unclear. In this study, we evaluated that the antioxidant and anti-inflammatory effect of S. horneri ethanolic extract and its subfractions using lipopolysaccharide (LPS)-treated RAW264.7 cells. Furthermore, we examined the in vivo anti-obesity efficacy of S. horneri using obese mice fed a high-fat diet. Results revealed that the in vitro treatment increases the inflammatory cytokines such as inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE

Indexed as

AMP-Activated Protein KinasesHeme Oxygenase-1InflammationNF-E2-Related Factor 2ObesitySargassumSignal TransductionAnimalsAnti-Inflammatory AgentsAnti-Obesity AgentsCytokinesDiet, High-FatLipopolysaccharidesMaleMembrane ProteinsMiceAMP-Activated Protein KinasesAnti-Inflammatory AgentsAnti-Obesity AgentsCytokinesHeme Oxygenase-1Hmox1 protein, mouseLipopolysaccharidesMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2Plant ExtractsAMPK signaling pathwayAnti-inflammatory effectAnti-obesity effectICR miceNuclear factor kappa BSargassum horneri

Identifiers

PMID41372250
PMCPMC12695935

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.