SynthesisNature communications2025
The genetic architecture of brainstem structures.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors.
Hui Xue *Department of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Jilian Fu *Department of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Zuojun Geng *Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID http://orcid.org/0000-0001-9944-8419
Meiyun WangDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.ORCID http://orcid.org/0000-0003-4454-5005
Longjiang ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-6664-7224
Guangbin CuiFunctional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Hui ZhangDepartment of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Bo GaoDepartment of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-0127-2812
Tong HanDepartment of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Quan ZhangDepartment of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China.
Wen QinDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0002-9121-8296
Feng LiuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0002-3570-4222
Meng LiangSchool of Medical Imaging and School of Medical Technology, Tianjin Medical University, Tianjin, China.ORCID http://orcid.org/0000-0003-0916-520X
Sijia WangDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0001-8949-303X
Qiang XuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Jiayuan XuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0001-9473-1047
Caihong WangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Nana LiuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Yuan JiDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0003-2874-5904
Peng ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Wei LiDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Wei WeiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
Dapeng ShiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
Su LuiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Feng ChenDepartment of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.ORCID http://orcid.org/0000-0002-9129-7895
Jing ZhangDepartment of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China.
Wen ShenDepartment of Radiology, Tianjin First Center Hospital, Tianjin, China.
Yanwei MiaoDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Jia-Hong GaoCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9311-0297
Yunjun YangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kai XuDepartment of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.ORCID http://orcid.org/0000-0001-5407-5671
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-2191-9393
Bing ZhangDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-3953-0290
Xiaochu ZhangDivision of Life Science and Medicine, University of Science & Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-7541-0130
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0001-9110-585X
Mulin Jun LiDepartment of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID http://orcid.org/0000-0003-3598-3679
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.ORCID http://orcid.org/0000-0003-3157-8393
Shijun QiuDepartment of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China. qiu-sj@163.com.ORCID http://orcid.org/0000-0002-6739-4265
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. zhuwenzhen8612@163.com.ORCID http://orcid.org/0000-0001-6252-9450
Chunshui YuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn.ORCID http://orcid.org/0000-0001-5648-5199
CHIMGEN Consortium
Funding
National Natural Science Foundation of China (National Science Foundation of China) 81425013National Natural Science Foundation of China (National Science Foundation of China) 82030053National Natural Science Foundation of China (National Science Foundation of China) 82402253National Natural Science Foundation of China (National Science Foundation of China) 82430063
Abstract
The brainstem houses numerous nuclei and tracts that serve vital functions. Genome-wide associations with brainstem substructure volumes have been explored in European individuals, yet other ancestries remain under-represented. Here, we conduct cross-ancestry genome-wide association meta-analyses in 103,098 individuals for brainstem and 78,062 individuals for eight substructure volumes, including 7094 Chinese Han individuals. We identify 713 locus-trait associations with brainstem and substructure volumes at P < 5.56 ×10
Indexed as
Brain StemEast Asian PeopleFemaleGenome-Wide Association StudyHumansMalePhenotypePolymorphism, Single NucleotideQuantitative Trait Loci
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.